TY - JOUR T1 - Alcohol-dependent effect of <em>PRSS1-PRSS2</em> haplotype in chronic pancreatitis JF - Gut JO - Gut DO - 10.1136/gutjnl-2019-319729 SP - gutjnl-2019-319729 AU - Eszter Hegyi AU - Anna Zsófia Tóth AU - Áron Vincze AU - Andrea Szentesi AU - Péter Hegyi AU - Miklós Sahin-Tóth Y1 - 2019/09/10 UR - http://gut.bmj.com/content/early/2019/09/09/gutjnl-2019-319729.abstract N2 - We read with great interest the studies by Derikx et al,1 Boulling et al2 and Masson et al,3 in which the authors report that a commonly occurring haplotype spanning the PRSS1-PRSS2 locus (encoding human cationic and anionic trypsinogen) is associated with chronic pancreatitis with an allelic OR of 0.7 in European cohorts (figure 1). Tagged by the c.-408C&gt;T variant (rs10273639), this haplotype was first identified in a GWAS by the Whitcomb laboratory.4 The small but significant protective effect is likely due to the c.-204C&gt;A promoter variant (rs4726576) in PRSS1, which decreases trypsinogen expression and thereby reduces the risk of premature trypsin activation in the pancreas.2 Curiously, Derikx et al1 found a clear association of the PRSS1-PRSS2 haplotype with alcoholic pancreatitis only, whereas no association was evident with non-alcoholic disease. Whitcomb et al also noted that the effect of the haplotype seemed to be amplified by alcohol.4 The French study did not specify disease aetiology.2 … ER -