TY - JOUR T1 - <em>RSPO2</em> abnormal transcripts result from read-through in liver tumours with high ß-catenin activation and <em>CTNNB1</em> mutations JF - Gut JO - Gut SP - 1152 LP - 1153 DO - 10.1136/gutjnl-2019-319089 VL - 69 IS - 6 AU - Quentin Bayard AU - Jean-Charles Nault AU - Jessica Zucman-Rossi Y1 - 2020/06/01 UR - http://gut.bmj.com/content/69/6/1152.abstract N2 - Thomas Longerich and collaborators1 recently published an intriguing observation in hepatocellular adenoma (HCA) showing an activation of the Wnt/ß-catenin signalling pathway without CTNNB1 or APC mutations. The authors identified a recurrent deletion leading to a fusion between a short interspersed nuclear element (SINE) sequence and RSPO2 gene in three HCAs and three hepatocellular carcinomas (HCCs) all activated for ß-catenin, including one tumour with CTNNB1 mutations and five tumours without APC or CTNNB1 mutations. The authors proposed RSPO2fusion as a recurrent mechanism of ß-catenin activation in liver tumourigenesis.Following this original observation, we analysed the expression and rearrangement of RSPO2 in a series of 10 HCAs and 163 HCCs analysed with RNAseq. We identified a correlation of RSPO2 mRNA expression with several genes known to be positively … ER -