RT Journal Article
SR Electronic
T1 Colon and rectal cancer survival in seven high-income countries 2010–2014: variation by age and stage at diagnosis (the ICBP SURVMARK-2 project)
JF Gut
JO Gut
FD BMJ Publishing Group Ltd and British Society of Gastroenterology
SP gutjnl-2020-320625
DO 10.1136/gutjnl-2020-320625
A1 Marzieh Araghi
A1 Melina Arnold
A1 Mark J Rutherford
A1 Marianne Grønlie Guren
A1 Citadel J Cabasag
A1 Aude Bardot
A1 Jacques Ferlay
A1 Hanna Tervonen
A1 Lorraine Shack
A1 Ryan R Woods
A1 Nathalie Saint-Jacques
A1 Prithwish De
A1 Carol McClure
A1 Gerda Engholm
A1 Anna T Gavin
A1 Eileen Morgan
A1 Paul M Walsh
A1 Christopher Jackson
A1 Geoff Porter
A1 Bjorn Møller
A1 Oliver Bucher
A1 Michael Eden
A1 Dianne L O’Connell
A1 Freddie Bray
A1 Isabelle Soerjomataram
YR 2020
UL http://gut.bmj.com/content/early/2020/06/01/gutjnl-2020-320625.abstract
AB Objectives As part of the International Cancer Benchmarking Partnership (ICBP) SURVMARK-2 project, we provide the most recent estimates of colon and rectal cancer survival in seven high-income countries by age and stage at diagnosis.Methods Data from 386 870 patients diagnosed during 2010–2014 from 19 cancer registries in seven countries (Australia, Canada, Denmark, Ireland, New Zealand, Norway and the UK) were analysed. 1-year and 5-year net survival from colon and rectal cancer were estimated by stage at diagnosis, age and country,Results (One1-year) and 5-year net survival varied between (77.1% and 87.5%) 59.1% and 70.9% and (84.8% and 90.0%) 61.6% and 70.9% for colon and rectal cancer, respectively. Survival was consistently higher in Australia, Canada and Norway, with smaller proportions of patients with metastatic disease in Canada and Australia. International differences in (1-year) and 5-year survival were most pronounced for regional and distant colon cancer ranging between (86.0% and 94.1%) 62.5% and 77.5% and (40.7% and 56.4%) 8.0% and 17.3%, respectively. Similar patterns were observed for rectal cancer. Stage distribution of colon and rectal cancers by age varied across countries with marked survival differences for patients with metastatic disease and diagnosed at older ages (irrespective of stage).Conclusions Survival disparities for colon and rectal cancer across high-income countries are likely explained by earlier diagnosis in some countries and differences in treatment for regional and distant disease, as well as older age at diagnosis. Differences in cancer registration practice and different staging systems across countries may have impacted the comparisons.