RT Journal Article
SR Electronic
T1 Outcomes of COVID-19 in 79 patients with IBD in Italy: an IG-IBD study
JF Gut
JO Gut
FD BMJ Publishing Group Ltd and British Society of Gastroenterology
SP 1213
OP 1217
DO 10.1136/gutjnl-2020-321411
VO 69
IS 7
A1 Bezzio, Cristina
A1 Saibeni, Simone
A1 Variola, Angela
A1 Allocca, Mariangela
A1 Massari, Alessandro
A1 Gerardi, Viviana
A1 Casini, Valentina
A1 Ricci, Chiara
A1 Zingone, Fabiana
A1 Amato, Arnaldo
A1 Caprioli, Flavio
A1 Lenti, Marco Vincenzo
A1 Viganò, Chiara
A1 Ascolani, Marta
A1 Bossa, Fabrizio
A1 Castiglione, Fabiana
A1 Cortelezzi, Claudio
A1 Grossi, Laurino
A1 Milla, Monica
A1 Morganti, Daniela
A1 Pastorelli, Luca
A1 Ribaldone, Davide Giuseppe
A1 Sartini, Alessandro
A1 Soriano, Alessandra
A1 Manes, Gianpiero
A1 Danese, Silvio
A1 Fantini, Massimo
A1 Armuzzi, Alessandro
A1 Daperno, Marco
A1 Fiorino, Gionata
A1 ,
YR 2020
UL http://gut.bmj.com/content/69/7/1213.abstract
AB Objectives COVID-19 has rapidly become a major health emergency worldwide. Patients with IBD are at increased risk of infection, especially when they have active disease and are taking immunosuppressive therapy. The characteristics and outcomes of COVID-19 in patients with IBD remain unclear.Design This Italian prospective observational cohort study enrolled consecutive patients with an established IBD diagnosis and confirmed COVID-19. Data regarding age, sex, IBD (type, treatments and clinical activity), other comorbidities (Charlson Comorbidity Index (CCI)), signs and symptoms of COVID-19 and therapies were compared with COVID-19 outcomes (pneumonia, hospitalisation, respiratory therapy and death).Results Between 11 and 29 March 2020, 79 patients with IBD with COVID-19 were enrolled at 24 IBD referral units. Thirty-six patients had COVID-19-related pneumonia (46%), 22 (28%) were hospitalised, 7 (9%) required non-mechanical ventilation, 9 (11%) required continuous positive airway pressure therapy, 2 (3%) had endotracheal intubation and 6 (8%) died. Four patients (6%) were diagnosed with COVID-19 while they were being hospitalised for a severe flare of IBD. Age over 65 years (p=0.03), UC diagnosis (p=0.03), IBD activity (p=0.003) and a CCI score >1 (p=0.04) were significantly associated with COVID-19 pneumonia, whereas concomitant IBD treatments were not. Age over 65 years (p=0.002), active IBD (p=0.02) and higher CCI score were significantly associated with COVID-19-related death.Conclusions Active IBD, old age and comorbidities were associated with a negative COVID-19 outcome, whereas IBD treatments were not. Preventing acute IBD flares may avoid fatal COVID-19 in patients with IBD. Further research is needed.