PT - JOURNAL ARTICLE AU - Peters, Yonne AU - Schrauwen, Ruud W M AU - Tan, Adriaan C AU - Bogers, Sanne K AU - de Jong, Bart AU - Siersema, Peter D TI - Detection of Barrett’s oesophagus through exhaled breath using an electronic nose device AID - 10.1136/gutjnl-2019-320273 DP - 2020 Jul 01 TA - Gut PG - 1169--1172 VI - 69 IP - 7 4099 - http://gut.bmj.com/content/69/7/1169.short 4100 - http://gut.bmj.com/content/69/7/1169.full SO - Gut2020 Jul 01; 69 AB - Timely detection of oesophageal adenocarcinoma (OAC) and even more so its precursor Barrett’s oesophagus (BO) could contribute to decrease OAC incidence and mortality. An accurate, minimally-invasive screening method for BO for widespread use is currently not available. In a proof-of-principle study in 402 patients, we developed and cross-validated a BO prediction model using volatile organic compounds (VOCs) analysis with an electronic nose device. This electronic nose was able to distinguish between patients with and without BO with good diagnostic accuracy (sensitivity 91% specificity 74%) and seemed to be independent of proton pump inhibitor use, the presence of hiatal hernia, and reflux. This technique may enable an efficient, well-tolerated, and sensitive and specific screening method to select high-risk individuals to undergo upper endoscopy.