RT Journal Article
SR Electronic
T1 Detection of Barrett’s oesophagus through exhaled breath using an electronic nose device
JF Gut
JO Gut
FD BMJ Publishing Group Ltd and British Society of Gastroenterology
SP 1169
OP 1172
DO 10.1136/gutjnl-2019-320273
VO 69
IS 7
A1 Yonne Peters
A1 Ruud W M Schrauwen
A1 Adriaan C Tan
A1 Sanne K Bogers
A1 Bart de Jong
A1 Peter D Siersema
YR 2020
UL http://gut.bmj.com/content/69/7/1169.abstract
AB Timely detection of oesophageal adenocarcinoma (OAC) and even more so its precursor Barrett’s oesophagus (BO) could contribute to decrease OAC incidence and mortality. An accurate, minimally-invasive screening method for BO for widespread use is currently not available. In a proof-of-principle study in 402 patients, we developed and cross-validated a BO prediction model using volatile organic compounds (VOCs) analysis with an electronic nose device. This electronic nose was able to distinguish between patients with and without BO with good diagnostic accuracy (sensitivity 91% specificity 74%) and seemed to be independent of proton pump inhibitor use, the presence of hiatal hernia, and reflux. This technique may enable an efficient, well-tolerated, and sensitive and specific screening method to select high-risk individuals to undergo upper endoscopy.