TY - JOUR T1 - Clinical course and risk factors for mortality of COVID-19 patients with pre-existing cirrhosis: a multicentre cohort study JF - Gut JO - Gut SP - 433 LP - 436 DO - 10.1136/gutjnl-2020-321666 VL - 70 IS - 2 AU - Xiaolong Qi AU - Yanna Liu AU - Jitao Wang AU - Jonathan A Fallowfield AU - Jianwen Wang AU - Xinyu Li AU - Jindong Shi AU - Hongqiu Pan AU - Shengqiang Zou AU - Hongguang Zhang AU - Zhenhuai Chen AU - Fujian Li AU - Yan Luo AU - Mei Mei AU - Huiling Liu AU - Zhengyan Wang AU - Jinlin Li AU - Hua Yang AU - Huihua Xiang AU - Xiaodan Li AU - Tao Liu AU - Ming-Hua Zheng AU - Chuan Liu AU - Yifei Huang AU - Dan Xu AU - Xiaoguo Li AU - Ning Kang AU - Qing He AU - Ye Gu AU - Guo Zhang AU - Chuxiao Shao AU - Dengxiang Liu AU - Lin Zhang AU - Xun Li AU - Norifumi Kawada AU - Zicheng Jiang AU - Fengmei Wang AU - Bin Xiong AU - Tetsuo Takehara AU - Don C Rockey A2 - , Y1 - 2021/02/01 UR - http://gut.bmj.com/content/70/2/433.abstract N2 - COVID-19 has rapidly become a global challenge.1 We read with interest the article by Bezzio et al 1 that reported the characteristics and outcomes of COVID-19 patients with pre-existing IBD. Patients with pre-existing cirrhosis, who have immune dysfunction and poorer outcomes from acute respiratory distress syndrome (ARDS) than patients without cirrhosis, are also considered a high-risk population for COVID-19.2 3In previous studies, the proportion of COVID-19 patients with pre-existing liver conditions ranged from 2% to 11%.2 However, the clinical course and risk factors for mortality in these patients has not yet been reported.This retrospective multicentre study (COVID-Cirrhosis-CHESS, ClinicalTrials.gov NCT04329559) included consecutive adult patients with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and pre-existing cirrhosis from 16 designated hospitals in China between 31 December 2019 and 24 March 2020. Patient characteristics are summarised in table 1. Twenty-one COVID-19 patients with pre-existing cirrhosis (Child-Pugh class A, B and C in 16, 3 and 2 patients, respectively) were included in the analysis. The median age … ER -