PT  - JOURNAL ARTICLE
AU  - Ru Chen
AU  - Yong Liu
AU  - Guohui Song
AU  - Bianyun Li
AU  - Deli Zhao
AU  - Zhaolai Hua
AU  - Xinzheng Wang
AU  - Jun Li
AU  - Changqing Hao
AU  - Liwei Zhang
AU  - Shuzheng Liu
AU  - Jialin Wang
AU  - Jinyi Zhou
AU  - Yongzhen Zhang
AU  - Bo Li
AU  - Yanyan Li
AU  - Xiang Feng
AU  - Lin Li
AU  - Zhiwei Dong
AU  - Wenqiang Wei
AU  - Guiqi Wang
TI  - Effectiveness of one-time endoscopic screening programme in prevention of upper gastrointestinal cancer in China: a multicentre population-based cohort study
AID  - 10.1136/gutjnl-2019-320200
DP  - 2021 Feb 01
TA  - Gut
PG  - 251--260
VI  - 70
IP  - 2
4099  - http://gut.bmj.com/content/70/2/251.short
4100  - http://gut.bmj.com/content/70/2/251.full
SO  - Gut2021 Feb 01; 70
AB  - Objectives To estimate the effectiveness of endoscopic screening programme in reducing incidence and mortality of upper gastrointestinal cancer in high risks areas of China.Design This multicentre population-based cohort study was conducted in six areas in China from 2005 to 2015. All permanent residents aged 40 to 69 years were identified as target subjects. We refer to those who were invited for screening collectively as the invited group. Of these, we classify those who were invited and undertook endoscopic screening as the screened group and those who were invited but did not accept screening as the non-screened group. Target subjects who were not invited to the screening were assigned to the control group. The effectiveness of the endoscopic screening and screening programme were evaluated by comparing reductions in incidence and mortality from upper gastrointestinal cancer in the screened and invited group with control group.Results Our cohort analysis included 637 500 people: 299 483 in the control group and 338 017 in the invited to screening group, 113 340 (33.53%) of whom were screened eventually. Compared with subjects in the control group, upper gastrointestinal cancer incidence and mortality decreased by 23% (relative risk (RR)=0.77, 95% CI 0.74 to 0.81) and 57% (RR=0.43, 95% CI 0.40 to 0.47) in the screened group, respectively, and by 14% (RR=0.86, 95% CI 0.84 to 0.89) and 31% (RR=0.69, 95% CI 0.66 to 0.72) in the invited group, respectively.Conclusion Among individuals aged 40 to 69 years in high risk areas of upper gastrointestinal cancer, one-time endoscopic screening programme was associated with a significant decrease in upper gastrointestinal cancer incidence and mortality.