TY - JOUR T1 - Long-term effectiveness of faecal immunochemical test screening for proximal and distal colorectal cancers JF - Gut JO - Gut DO - 10.1136/gutjnl-2020-322545 SP - gutjnl-2020-322545 AU - Han-Mo Chiu AU - Grace Hsiao-Hsuan Jen AU - Ying-Wei Wang AU - Jean Ching-Yuan Fann AU - Chen-Yang Hsu AU - Ya-Chung Jeng AU - Amy Ming-Fang Yen AU - Sherry Yueh-Hsia Chiu AU - Sam Li-Sheng Chen AU - Wen-Feng Hsu AU - Yi-Chia Lee AU - Ming-Shiang Wu AU - Chien-Yuan Wu AU - Yann-Yuh Jou AU - Tony Hsiu-Hsi Chen Y1 - 2021/01/24 UR - http://gut.bmj.com/content/early/2021/01/24/gutjnl-2020-322545.abstract N2 - Objective To measure the effects of faecal immunochemical test (FIT) for colorectal cancer (CRC) screening on overall and site-specific long-term effectiveness of population-based organised service screening.Design A prospective cohort study of Taiwanese nationwide biennial FIT screening was performed. A total of 5 417 699 eligible subjects were invited to attend screening from 2004 through 2009 and were followed up until 2014. We estimated the adjusted relative rates (aRRs) on the effectiveness of reducing advanced-stage CRC (stage II+) and CRC death by Bayesian Poisson regression models with the full adjustment for a cascade of self-selection factors (including the screening rate and the colonoscopy rate) and the completeness of colonoscopy together with demographic features.Results FIT screening (exposed vs unexposed) reduced the incidence of advanced-stage CRC (48.4 vs 75.7 per 100 000) and mortality (20.3 vs 41.3 per 100 000). Statistically significant reductions of both incidence of advanced-stage CRCs (aRR=0.66, 95% CI 0.63 to 0.70) and deaths from CRC (aRR=0.60, 95% CI 0.57 to 0.64) were noted. FIT screening was more effective in reducing distal advanced-stage CRCs (aRR=0.61, 95% CI 0.58 to 0.64) and CRC mortality (aRR=0.56, 95% CI 0.53 to 0.69) than proximal advanced CRCs (aRR=0.84, 95% CI 0.77 to 0.92) and CRC mortality (aRR=0.72, 95% CI 0.66 to 0.80).Conclusion A large-scale population-based biennial FIT screening demonstrates 34% significant reduction of advanced-stage CRCs and 40% reduction of death from CRC with larger long-term effectiveness in the distal colon than the proximal colon. Our findings provide a strong and consistent evidence-based policy for supporting a sustainable population-based FIT organised service screening worldwide. The disparity of site-specific long-term effectiveness also provides an insight into the remedy for lower effectiveness of FIT screening in the proximal colon. ER -