RT Journal Article SR Electronic T1 SARS-CoV-2 infection in acute pancreatitis increases disease severity and 30-day mortality: COVID PAN collaborative study JF Gut JO Gut FD BMJ Publishing Group Ltd and British Society of Gastroenterology SP gutjnl-2020-323364 DO 10.1136/gutjnl-2020-323364 A1 Sanjay Pandanaboyana A1 John Moir A1 John S Leeds A1 Kofi Oppong A1 Aditya Kanwar A1 Ahmed Marzouk A1 Ajay Belgaumkar A1 Ajay Gupta A1 Ajith K Siriwardena A1 Ali Raza Haque A1 Altaf Awan A1 Anita Balakrishnan A1 Arab Rawashdeh A1 Bogdan Ivanov A1 Chetan Parmar A1 Christopher M Halloran A1 Clifford Caruana A1 Cynthia-Michelle Borg A1 Dhanny Gomez A1 Dimitrios Damaskos A1 Dimitrios Karavias A1 Guy Finch A1 Husam Ebied A1 James K Pine A1 James R A Skipworth A1 James Milburn A1 Javed Latif A1 Jeyakumar Ratnam Apollos A1 Jihène El Kafsi A1 John A Windsor A1 Keith Roberts A1 Kelvin Wang A1 Krish Ravi A1 Maria V Coats A1 Marianne Hollyman A1 Mary Phillips A1 Michael Okocha A1 Michael SJ Wilson A1 Nadeem A Ameer A1 Nagappan Kumar A1 Nehal Shah A1 Pierfrancesco Lapolla A1 Connor Magee A1 Bilal Al-Sarireh A1 Raimundas Lunevicius A1 Rami Benhmida A1 Rishi Singhal A1 Srinivasan Balachandra A1 Semra Demirli Atıcı A1 Shameen Jaunoo A1 Simon Dwerryhouse A1 Tamsin Boyce A1 Vasileios Charalampakis A1 Venkat Kanakala A1 Zaigham Abbas A1 Manu Nayar A1 , YR 2021 UL http://gut.bmj.com/content/early/2021/03/03/gutjnl-2020-323364.abstract AB Objective There is emerging evidence that the pancreas may be a target organ of SARS-CoV-2 infection. This aim of this study was to investigate the outcome of patients with acute pancreatitis (AP) and coexistent SARS-CoV-2 infection.Design A prospective international multicentre cohort study including consecutive patients admitted with AP during the current pandemic was undertaken. Primary outcome measure was severity of AP. Secondary outcome measures were aetiology of AP, intensive care unit (ICU) admission, length of hospital stay, local complications, acute respiratory distress syndrome (ARDS), persistent organ failure and 30-day mortality. Multilevel logistic regression was used to compare the two groups.Results 1777 patients with AP were included during the study period from 1 March to 23 July 2020. 149 patients (8.3%) had concomitant SARS-CoV-2 infection. Overall, SARS-CoV-2-positive patients were older male patients and more likely to develop severe AP and ARDS (p<0.001). Unadjusted analysis showed that SARS-CoV-2-positive patients with AP were more likely to require ICU admission (OR 5.21, p<0.001), local complications (OR 2.91, p<0.001), persistent organ failure (OR 7.32, p<0.001), prolonged hospital stay (OR 1.89, p<0.001) and a higher 30-day mortality (OR 6.56, p<0.001). Adjusted analysis showed length of stay (OR 1.32, p<0.001), persistent organ failure (OR 2.77, p<0.003) and 30-day mortality (OR 2.41, p<0.04) were significantly higher in SARS-CoV-2 co-infection.Conclusion Patients with AP and coexistent SARS-CoV-2 infection are at increased risk of severe AP, worse clinical outcomes, prolonged length of hospital stay and high 30-day mortality.