TY - JOUR T1 - SARS-CoV-2 infection in acute pancreatitis increases disease severity and 30-day mortality: COVID PAN collaborative study JF - Gut JO - Gut SP - 1061 LP - 1069 DO - 10.1136/gutjnl-2020-323364 VL - 70 IS - 6 AU - Sanjay Pandanaboyana AU - John Moir AU - John S Leeds AU - Kofi Oppong AU - Aditya Kanwar AU - Ahmed Marzouk AU - Ajay Belgaumkar AU - Ajay Gupta AU - Ajith K Siriwardena AU - Ali Raza Haque AU - Altaf Awan AU - Anita Balakrishnan AU - Arab Rawashdeh AU - Bogdan Ivanov AU - Chetan Parmar AU - Christopher M Halloran AU - Clifford Caruana AU - Cynthia-Michelle Borg AU - Dhanny Gomez AU - Dimitrios Damaskos AU - Dimitrios Karavias AU - Guy Finch AU - Husam Ebied AU - James K Pine AU - James R A Skipworth AU - James Milburn AU - Javed Latif AU - Jeyakumar Ratnam Apollos AU - Jihène El Kafsi AU - John A Windsor AU - Keith Roberts AU - Kelvin Wang AU - Krish Ravi AU - Maria V Coats AU - Marianne Hollyman AU - Mary Phillips AU - Michael Okocha AU - Michael SJ Wilson AU - Nadeem A Ameer AU - Nagappan Kumar AU - Nehal Shah AU - Pierfrancesco Lapolla AU - Connor Magee AU - Bilal Al-Sarireh AU - Raimundas Lunevicius AU - Rami Benhmida AU - Rishi Singhal AU - Srinivasan Balachandra AU - Semra Demirli Atıcı AU - Shameen Jaunoo AU - Simon Dwerryhouse AU - Tamsin Boyce AU - Vasileios Charalampakis AU - Venkat Kanakala AU - Zaigham Abbas AU - Manu Nayar A2 - , Y1 - 2021/06/01 UR - http://gut.bmj.com/content/70/6/1061.abstract N2 - Objective There is emerging evidence that the pancreas may be a target organ of SARS-CoV-2 infection. This aim of this study was to investigate the outcome of patients with acute pancreatitis (AP) and coexistent SARS-CoV-2 infection.Design A prospective international multicentre cohort study including consecutive patients admitted with AP during the current pandemic was undertaken. Primary outcome measure was severity of AP. Secondary outcome measures were aetiology of AP, intensive care unit (ICU) admission, length of hospital stay, local complications, acute respiratory distress syndrome (ARDS), persistent organ failure and 30-day mortality. Multilevel logistic regression was used to compare the two groups.Results 1777 patients with AP were included during the study period from 1 March to 23 July 2020. 149 patients (8.3%) had concomitant SARS-CoV-2 infection. Overall, SARS-CoV-2-positive patients were older male patients and more likely to develop severe AP and ARDS (p<0.001). Unadjusted analysis showed that SARS-CoV-2-positive patients with AP were more likely to require ICU admission (OR 5.21, p<0.001), local complications (OR 2.91, p<0.001), persistent organ failure (OR 7.32, p<0.001), prolonged hospital stay (OR 1.89, p<0.001) and a higher 30-day mortality (OR 6.56, p<0.001). Adjusted analysis showed length of stay (OR 1.32, p<0.001), persistent organ failure (OR 2.77, p<0.003) and 30-day mortality (OR 2.41, p<0.04) were significantly higher in SARS-CoV-2 co-infection.Conclusion Patients with AP and coexistent SARS-CoV-2 infection are at increased risk of severe AP, worse clinical outcomes, prolonged length of hospital stay and high 30-day mortality.No data are available. ER -