TY - JOUR T1 - Selecting optimal patients with gastroparesis for G-POEM procedure JF - Gut JO - Gut SP - 659 LP - 660 DO - 10.1136/gutjnl-2021-324631 VL - 71 IS - 4 AU - Ting Zheng AU - Michael Camilleri Y1 - 2022/04/01 UR - http://gut.bmj.com/content/71/4/659.abstract N2 - In a very welcome article, Vosoughi and colleagues1 describe the experience from five tertiary centres (four in the USA, one in Brazil) regarding the outcomes of the gastric peroral endoscopic myotomy (G-POEM) procedure for the treatment of 80 patients with symptomatic gastroparesis refractory to standard medical therapy and confirmed by impaired gastric emptying (gastric retention >20% at 4 hours). The primary endpoint was clinical success, defined as at least one score decrease in the Gastroparesis Cardinal Symptom Index (GCSI) with ≥25% decrease in two subscales at 12 months. From this open-label, uncontrolled experience, the authors concluded that G-POEM was only modestly effective in patient with gastroparesis, with a clinical success rate of 56% at 12 months. However, serial assessment documented that the response to G-POEM was durable over the 12-month follow-up. This study also identified that baseline GCSI score >2.6 and baseline gastric retention greater than 20% at 4 hours, as well as responsiveness 1 month after the G-POEM procedure were independent predictors of clinical success 12 months after G-POEM.The study has many strengths including the sample size of 80, of which 94% had completed 12-month follow-up, use of the validated GCSI score and subscales, and assessment of quality of life, using the 36-Item Short Form Questionnaire, at baseline and 1, 3, 6 and … ER -