Liver and body weights, serum hormone concentrations, and cytosolic hormone receptor concentrations in DEN-AAF-PH treated rats
| Group treatment number | Weight | Serum concentrations | Hepatic receptor concentrations | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Body (g) | Liver (g) | Oestradiol (pg/ml) | Testosterone (ng/ml) | Oestrogen (fmol/mg protein) | Androgen | ||||
| Males | |||||||||
| 1 PH control | 273 (4) | 9.0 (0.8) | 59 (8) | 1.3 (0.5) | 15.2 (2.7) | 1.2 (0.4) | |||
| 2 DEN-AAF-PH | 220 (14)1-151 | 9.1 (0.9) | 43 (8)1-151 | 1.2 (0.5) | 11.6 (2.0)1-151 | 1.4 (0.6) | |||
| 3 DEN-AAF-PH + oestradiol | 170 (11)1-151 1-150 | 7.0 (1.7) | 238 (137)1-151 1-150 | 0.4 (0.1)1-151 | 10.8 (3.1)1-151 | 0.9 (0.3) | |||
| 4 DEN-AAF-PH + testosterone | 192 (15)1-151 1-150 | 7.6 (1.8) | 79 (11)1-150 | 0.8 (0.4) | 11.1 (3.7) | 0.8 (0.3) | |||
| 5 Orchiectomy + DEN-AAF-PH | 184 (15)1-151 1-150 | 8.4 (0.6) | 41 (101-151) | 0.8 (0.6) | 17.0 (4.2)1-150 | 1.4 (0.5) | |||
| 6 Orchiectomy + DEN-AAF-PH + oestradiol replacement | 148 (8)1-151 1-150 1-152 | 6.9 (0.3)1-151 1-150 1-152 | 147 (59)1-151 1-150 1-152 | <0.21-151 1-152 | 15.6 (1.8)1-150 | 0.8 (0.3)1-152 | |||
| Females | |||||||||
| 7 PH control | 161 (3) | 3.9 (0.6) | 110 (8) | <0.2 | 18.8 (4.4) | <0.1 | |||
| 8 DEN-AAF-PH | 144 (4)1-151 | 4.0 (1.0) | 79 (15)1-151 | <0.2 | 14.9 (3.0) | <0.1 | |||
| 9 Ovariectomy + DEN-AAF-PH | 153 (3)1-151 1-150 | 6.3 (0.6)1-150 | 72 (21)1-151 | <0.2 | 140 (1.9) | 0.7 (0.4)1-151 1-150 | |||
| 10 Ovariectomy + DEN-AAF-PH + testosterone replacement | 160 (8)1-150 | 6.9 (0.4)1-150 | 40 (9)1-151 1-150 1-152 | <0.2 | 14.2 (3.0) | 1.1 (0.5)1-151 1-150 | |||
Values are expressed as mean (SD).
↵1-150 p<0.05 versus corresponding value for DEN-AAF-PH in the same sex group.
↵1-151 p<0.05 versus corresponding value for PH control in the same sex group.
↵1-152 p<0.05 versus corresponding value for castration + DEN-AAF-PH in the same sex group (two tailed Mann-Whitney U test).