Clinical data and absorption, elimination, and synthesis of cholesterol in 24 patients with an ileoanal anastomosis and 20 control subjects
| Case no | Age (y) | Sex (F/M) | Body weight (kg) | BMI (kg/m2) | Postoperative period (months) | Intestinal transit time (h) | Absorption of vitamin B12 (% of dose/24 h) | Faecal fat (g/day) | Cholesterol absorption (%) | Faecal steroids (mg/day) | Cholesterol synthesis (mg/day) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Bile acids | Neutral steroids | ||||||||||||||||||||||
| 1 | 27 | F | 55 | 19.0 | 6 | 6.3 | 16.9 | 1.9 | 48.6 | 342 | 352 | 394 | |||||||||||
| 2 | 35 | F | 55 | 19.5 | 13 | 2.8 | 16.5 | 3.0 | 21.8 | 356 | 601 | 657 | |||||||||||
| 3 | 36 | F | 61 | 24.4 | 14 | 4.2 | 17.5 | 2.7 | 36.3 | 375 | 346 | 421 | |||||||||||
| 4 | 48 | F | 86 | 34.9 | 4 | 4.0 | 22.4 | 2.0 | 30.8 | 471 | 538 | 709 | |||||||||||
| 5 | 30 | F | 69 | 26.3 | 5 | 2.8 | 17.9 | 6.5 | 51.6 | 1525 | 561 | 1786 | |||||||||||
| 6 | 42 | F | 66 | 26.4 | 25 | 1.8 | 16.5 | 6.9 | 44.7 | 1357 | 778 | 1835 | |||||||||||
| 7 | 37 | F | 64 | 22.4 | 5 | 3.7 | 11.7 | 2.8 | 34.2 | 473 | 581 | 754 | |||||||||||
| 8 | 38 | M | 71 | 21.4 | 6 | 7.3 | 25.5 | 2.9 | 40.7 | 422 | 420 | 542 | |||||||||||
| 9 | 38 | F | 50 | 19.1 | 41 | 7.6 | 20.7 | 3.0 | 47.5 | 463 | 381 | 544 | |||||||||||
| 10 | 40 | M | 106 | 28.5 | 59 | 8.7 | 13.2 | 3.4 | 21.7 | 415 | 804 | 919 | |||||||||||
| 11 | 29 | F | 54 | 20.3 | 4 | 4.2 | 15.2 | 3.0 | 33.5 | 381 | 846 | 927 | |||||||||||
| 12 | 46 | F | 56 | 20.1 | 6 | 6.7 | 29.3 | 3.3 | 30.7 | 273 | 463 | 436 | |||||||||||
| 13 | 26 | M | 69 | 23.9 | 6 | 3.4 | 20.1 | 2.9 | 48.5 | 1048 | 400 | 1178 | |||||||||||
| 14 | 41 | F | 84 | 32.8 | 9 | 2.7 | 29.7 | 2.5 | 41.6 | 378 | 472 | 550 | |||||||||||
| 15 | 43 | M | 64 | 20.9 | 10 | 8.4 | 10.5 | 8.7 | 20.1 | 807 | 565 | 1072 | |||||||||||
| 16 | 40 | F | 66 | 23.9 | 4 | 4.8 | 27.8 | 2.3 | 29.2 | 932 | 355 | 987 | |||||||||||
| 17 | 29 | F | 63 | 21.3 | 6 | 5.5 | 23.0 | 2.2 | 38.2 | 429 | 520 | 649 | |||||||||||
| 18 | 56 | M | 70 | 25.1 | 12 | 4.0 | 18.7 | 5.1 | 291 | 1030 | 739 | 1469 | |||||||||||
| Mean (SEM) for cases 1–18 | 38 (2)*** | 13/5 | 67.2 (3.2)1-150 | 23.9 (1.1) | 13.1 (3.5) | 4.9 (0.5) | 19.6 (1.4) | 3.6 (0.4) | 36.0 (2.3)** | 575 (87) | 537 (38) | 878 (104) | |||||||||||
| 19 | 40 | M | 54 | 19.1 | 31 | 7.4 | ND | 5.5 | 43.3 | 436 | 674 | 810 | |||||||||||
| 20 | 50 | M | 80 | 27.0 | 51 | 24.8 | 23.8 | 3.9 | 24.7 | 778 | 563 | 1041 | |||||||||||
| 21 | 38 | M | 55 | 19.0 | 34 | 7.3 | 24.1 | 2.6 | 36.7 | 625 | 469 | 794 | |||||||||||
| 22 | 54 | M | 101 | 31.9 | 24 | 5.3 | 19.7 | 2.7 | 42.1 | 815 | 374 | 889 | |||||||||||
| 23 | 37 | M | 66 | 19.7 | 8 | 6.2 | 18.9 | 3.7 | 33.9 | 1039 | 620 | 1359 | |||||||||||
| 24 | 24 | M | 67 | 19.8 | 36 | 4.5 | ND | 4.9 | 35.0 | 1274 | 593 | 1567 | |||||||||||
| Mean for cases 19–24 | 41 (4)1-150 | 0/6 | 70.5 (7.2) | 22.8 (2.2) | 30.7 (5.8)† | 9.2 (3.1) | 21.6 (1.4) | 3.9 (0.5) | 36.0 (2.7)** | 828 (121)** | 548 (45) | 1077 (130) | |||||||||||
| Controls (n=20) | 50 (1) | 0/20 | 75.5 (1.8) | 24.3 (0.5) | ND | ND | > 12 | 4.6 (0.5) | 47.0 (1.6)‡ | 437 (34) | 749 (71) | 827 (110) | |||||||||||
Patients 1–18 had no history of pouchitis; patients 19–24 had a history of pouchitis.
↵1-150 p < 0.05, **p < 0.01, ***p < 0.001, †p < 0.01 from non-pouchitis group; ‡n = 15; ND, not done.