Clinical tolerance, faecal characteristics and breath H2 excretion in lactose intolerant subjects during a 50 g lactose challenge before (day 1) and after (day 15) prolonged consumption of lactose (n=24) or sucrose (n=22)
| Day 1 | Day 2 | Difference in adjusted means lactose–sucrose (95% CI) | p Value (ANCOVA) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Lactose group | Sucrose | Lactose group | Sucrose group | ||||||||
| Clinical score (0–144) | 42.1 (19.9) | 42.0 (15.2) | 20.2 (13.9)‡ | 24.2 (12.8)‡ | −4.0 (−11.7 to 3.7) | NS | |||||
| Number of stools | 3.7 (1.5) | 4.2 (2.7) | 2.0 (1.2)‡ | 2.4 (1.8)† | −0.3 (−1.2 to 0.6) | NS | |||||
| Faecal weight (g/24 h) | 350 (199) | 410 (252) | 311 (230) | 345 (231) | −0.8 (−141 to 125) | NS | |||||
| Osmotic gap (mOsm/kg) | 139 (61) | 137 (51) | 115 (55) | 126 (36) | −11.5 (−40 to 18) | NS | |||||
| Faecal pH | 5.9 (0.4) | 6.1 (0.7) | 5.3 (0.5)† | 6.1 (0.8) | −0.6 (−1.0 to −0.2) | NS | |||||
| Orofaecal transit time (min) | 336 (243) | 324 (284) | 489 (259)1-150 | 443 (288) | 42 (−116 to 200) | NS | |||||
| Breath H2 excretion (ml) | 235 (110) | 177 (96) | 102 (96)‡ | 191 (103) | −114 (−171 to −57) | <0.0001 | |||||
| Faecal β-galactosidase activity (IU/g) | 10.1 (5.6) | 10.6 (6.6) | 20.2 (15.3)† | 6.7 (3.7)1-150 | 13.8 (7.2 to 20.4) | <0.0001 | |||||
Results are expressed as means (SD).
↵1-150 p v the same group during the first challenge on day 1 <0.05; †p<0.005; ‡p<0.0001.