Biliary lipids, lithogenic index, and bile acid composition and secretion in control subjects and patients with an ileoanal anastomosis
| Parameter | Controls (n=15) | Patients without pouchitis history (n=16) | Patients with pouchitis history (n=6) |
| Biliary lipids (molar %) | |||
| Cholesterol | 8.3 (0.7) | 11.3 (1.0)** | 9.2 (1.1) |
| Bile acids | 70.7 (1.2) | 69.8 (2.2) | 70.0 (2.2) |
| Phospholipids | 21.0 (0.9) | 18.9 (1.4) | 20.5 (1.0) |
| Lithogenic index | 0.83 (0.07) | 1.16 (0.09) | 0.92 (0.10) |
| Biliary bile acids (% distribution) | |||
| Cholic acid | 47.1 (2.5) | 56.5 (1.9)** | 60.7 (3.3)** |
| Deoxycholic acid | 11.9 (1.8) | 0.9 (0.6)*** | 0.03 (0.01)*** |
| Chenodeoxycholic acid | 37.3 (1.6) | 40.9 (1.4) | 38.6 (3.2) |
| Lithocholic acid | 1.7 (0.4) | 0.22 (0.03)*** | 0.12 (0.03)*** |
| Ursodeoxycholic acid | 1.9 (0.5) | 1.4 (0.4) | 0.5 (0.3)7-150 |
Results expressed as mean (SEM).
↵7-150 p < 0.05, **p < 0.01, ***p < 0.001 versus control values.