Table 2

 Comparison of baseline electrophysiological parameters in intestinal tissues in chloride containing or chloride free buffer

Specimen site Pathological condition Treatment Isc (μA/cm2) PD (mV) G (mS/cm2)
Small bowel
Non-IBDCl+79.0  (28.0)3.6  (1.2)21.5  (2.8)
Cl−27.9 (12.2)2.0 (0.7)13.5 (2.9)
Crohn’s diseaseCl+63.9 (8.0)3.4 (0.5)23.0 (2.5)
Cl−33.3 (5.6)* 2.7 (0.4)14.2 (0.9)*
Large bowel
Non-IBDCl+140.0 (36.4)15.2 (3.2)8.7 (0.7)
Cl−60.6 (11.1)* 15.1 (2.2)7.4 (0.4)
Crohn’s diseaseCl+156.8 (24.1)13.2 (4.1)22.4 (6.0)
Cl−74.1 (22.2)* 9.7 (3.7)18.3 (5.6)
Ulcerative colitisCl+49.7 (9.9)5.0 (1.0)9.9 (0.8)
Cl−17.8 (4.8)* 3.3 (0.5)4.1 (1.2)*
  • Values are mean (SEM), n = 3–7 subjects per group with equal numbers of tissues treated with chloride containing buffer (Cl+) or chloride free buffer (Cl−). *p<0.05 compared with Cl+.