Comparison of patients with Crohn’s disease treated with enteral nutrition (n=12, 7M/5F) or prednisolone (n=12, 10M/2F)
Treatment | 0 Months | One month | Three months | |
Age (y) | Enteral nutrition | 12.8 (15.9) | – | – |
Prednisolone | 13.95 (1.8) | – | – | |
Height (cm) | Enteral nutrition | 147.2 (15.9) | 147.0 (17.3) | 147.1 (16.7) |
Prednisolone | 156.7 (9.9) | 157.0 (9.5) | 156.6 (10.7) | |
Weight (kg) | Enteral nutrition | 32.6 (8.8)a | 38.2 (11.7)b | 40.9 (12.1)c |
Prednisolone | 41.0 (9.0)a | 47.3 (9.0)b | 51.4 (10.3)c | |
IBW (%) | Enteral nutrition | 83.9 (11.3)a | 97.9 (15.8)b | 106 (13.8)c |
Prednisolone | 89.1 (9.8)a | 103.9 (15.6)b | 114.2 (17.9)c | |
REE (kcal/day) | Enteral nutrition | 1153 (283)a | 1415 (535)b | 1453 (307)c |
Prednisolone | 1380 (308)a | 1432 (265)a | 1592 (362)b | |
REE (% predicted) | Enteral nutrition | 96.6 (13.1)a | 108.7 (21)A,b | 110 (114.4)B, b |
Prednisolone | 100.8 (15.9) | 97.4 (13.6)C | 102.9 (16.2)D | |
LBM | Enteral nutrition | 27.56 (10.1)a | 32.5 (11.6)b | 34.7 (10.6)c |
Prednisolone | 34.5 (8.2)a | 39.06 (10.7)b | 38.9 (10.8)b | |
LBM (%wt) | Enteral nutrition | 86.6 (8.9) | 88.8 (9.9) | 83.2 (5.7) |
Prednisolone | 87.5 (9.4) | 79.1 (9.4) | 77.7 (11.4) | |
Fat (%wt) | Enteral nutrition | 16.19 (4.7)a | 20.8 (5.2)b | 22.0 (5.7)c |
Prednisolone | 17.4 (4.0)a | 20.5 (5.5)b | 24.1 (5.9)c | |
TBW (L) | Enteral nutrition | 20.12 (4.8)a | 23.7 (8.4)A,b | 25.4 (7.8)B,c |
Prednisolone | 25.2 (6.0)a | 25.8 (7.8)C,b | 28.4 (7.9)D,b | |
ECW (L) | Enteral nutrition | 9.24 (2.7)a | 9.2 (4.7)A,b | 10.7 (5.5)B,c |
Prednisolone | 11.07 (2.3)a | 12.8 (2.3)C,b | 11.56 (2.7)D,c | |
ICW (L) | Enteral nutrition | 10.6 (3.1)a | 13.5 (4.9)b | 13.9 (4.7)A,b |
Prednisolone | 14.1 (4.9)a | 17.8 (4.56)b | 16.9 (5.6)B,b | |
ECW (%wt) | Enteral nutrition | 29.0 (3.5)a | 25.2 (8.9)b | 25.4 (10.3)b |
Prednisolone | 28.4 (4.7)a | 25.0 (2.7)b | 23.1 (2.5)c | |
ECW/ICW | Enteral nutrition | 0.94 (0.27)a | 0.77 (0.09)b | 0.73 (0.33)b |
Prednisolone | 0.88 (0.45) | 0.73 (0.12) | 0.72 (0.16) |
Values are expressed as mean (SD).
0 Months, before treatment; one month, one month after treatment; three months, three months after treatment.
There was no statistically significant difference between the two groups before treatment.
IBW, ideal body weight; REE, resting energy expenditure; LBM, lean body mass; TBW, total body water; ICW, intracellular water; ECW, extracellular water.
Lower case superscript letters denote comparisons within subject across the 0, one and three month time points in each of the two treatment groups. Means with different superscripts are significantly different (p<0.05).
Differences in the response to treatment between treatment groups (enterally fed compared with prednisolone treated) are shown using superscript capital letters. Responses to treatment were tested as the changes from before treatment (0 months) to either one month or three months. Means with different superscripts are significantly different (p<0.05).