Haemodynamics of 142 cirrhotic patients without hepatic encephalopathy stratified according to the modified Child-Turcotte criteria
| Variable | Child class A (n=41) | Child class B (n=57) | Child class C (n=44) |
| Systemic haemodynamics3-152 | |||
| Mean arterical blood pressure (mm Hg) | 94 (69–122) | 87 (68–120)* | 80 (60–112)† |
| Heart rate (beats/min) | 73 (54–108) | 79 (54–104)* | 85 (60–108)† |
| Cardiac index (l/min/m2) | 3.3 (2.1–5.1) | 3.7 (2.1–5.7) | 4.3 (1.9–6.5)† |
| Central circulation time (seconds) (>14) | 15.6 (10.0–23.4) | 13.1 (7.9–21.8)** | 11.2 (7.3–21.1)† |
| Central and arterial blood volume (ml/kg ideal body weight) (>24) | 23.7 (16.0–37.6) | 22.8 (16.1–34.7) | 21.1 (13.8–31.2)* |
| Systemic vascular resistance (dyn/s/cm5) (>1600) | 1323 (578–2424) | 1102 (565–2370)** | 864 (431–1493)† |
| Plasma volume (l) (2.70–3.80) | 3.63 (1.80–6.16) | 3.91 (2.00–6.27) | 3.98 (2.39–5.70) |
| Splanchnic characteristics3-152 | |||
| Hepatic venous pressure gradient (mm Hg) (<5) | 11.6 (3.0–21.0) | 15.2 (5.0–29.0)** | 17.6 (5.0–28.0)† |
| Postsinusoidal resistance (dyn/s/cm5) (<360) | 943 (236–3644) | 1164 (330–4343) | 1448 (232–4432)** |
| Hepatic blood flow (l/min) (0.5–2.3) | 1.13 (0.44–2.39) | 1.30 (0.33–2.87) | 1.15 (0.35–2.63) |
| ICG clearance (l/min) (0.30–0.70) | 0.30 (0.09–0.60) | 0.23 (0.05–0.60)** | 0.16 (0.01–0.68)† |
| Galactose elimination capacity (mmol/min) (F >14; M >17) | 1.95 ( 0.93–2.86) | 1.55 (0.78–2.60)** | 1.28 (0.01–2.14)† |
Results are expressed as mean (range).
Significance of differences between patient groups: *p<0.05v Child class A; **p<0.01 v Child class A;†p<0.005 v Child classes A and B.
↵3-152 Normal values are given in parentheses.