Gut sensitivity and sphincter function on active drug and placebo
| R093877 (1 mg) v placebo | R093877 (2 mg) v placebo | |
| Resting anal sphincter pressure (mmHg) | 109 (96–128) v 102 (84–120) | 102 (68–128) v 100 (60–120) |
| Threshold distension volume (ml) | 38 (25–55) v 34 (20–45) | 57 (20–100) v 50 (15–90) |
| Urge distension volume (ml) | 71 (50–95) v 62 (45–85) | 105 (45–180) v 93 (30–180) |
| Maximum tolerated volume (ml) | 137 (80–210) v 131 (75–190) | 184 (130–255) v 184 (110–250) |
| Anal electrosensory threshold (mA) | 4.0 (2.2–5.9) v 3.9 (1.7–6.1) | 4.4 (3.8–5.2) v 4.8 (3.8–7.2) |
| Rectal electrosensory threshold (mA) | 9.2 (3.8–19.9)v 8.7 (3.1–18.8) | 10.7 (4.5–21.2) v12.5 (4.9–22.5) |
Values are mean (range).