Genotypes of NAT in intestinal samples
Sample | NAT1 | PABA activity (nmol/min/mg protein) | NAT2 | SMZ activity (nmol/min/mg protein) | |||||
---|---|---|---|---|---|---|---|---|---|
Genotype | Phenotype | ||||||||
A (11/5) | 1*4, 1*4 | 6.1 (0.2) | 2*4, 2*5B | FS | 0.85 (0.01) | ||||
B (18/5) | 1*4, 1*14 | 2.1 (0.1) | 2*4, 2*4 | FF | 1.18 (0.03) | ||||
C (22/3) | 1*4, 1*4 | 6.9 (0.3) | 2*5B, 2*6A | SS | 0.22 (0.02) | ||||
D (24/3) | 1*4, 1*4 | 7.5 (0.1) | 2*5B, 2*5B | SS | 0.23 (0.01) |
The names of alleles are as described in Vatsis et al.10 The phenotype of NAT2 has been determined from the genotype and is shown to indicate fast alleles as āFā and slow alleles as āSā. Activities with sulphamethazine (SMZ) orp-aminobenzoic acid (PABA) are the values for the most proximal section of intestine in each case and are the mean (SD) of four individual estimations.