Holloway et al6 | Penagini et al | |
Subjects | 12 N + 11 GORD | 13 N + 14 GORD |
Meals | Liquid; intraduodenal infusion (1 ml/min for 30 min) of fat (Intralipid 10%) vsaline | Solid + liquid (3.18 MJ); Orally + intragastric infusion of a high fat (52%) v a balanced (24%) meal |
Duration of recording | 30 min | 180 min |
Results | ||
Basal LOS pressure | ||
Normal controls | Decreased | NS |
GORD | NS | NS |
TLOSRs | ||
Normal controls | NS | NS |
GORD | NS | NS |
No of reflux episodes | ||
Normal controls | NS | NS |
GORD | Increased | NS |
% TLOSRs with reflux | ||
Normal controls | NS | NS |
GORD | Increased | NS |
N, asymptomatic healthy subjects; GORD, patients with erosive oesophagitis or abnormal acid exposure, or both, on 24 hour pH monitoring.