Patient survival (mean (SEM)) from colorectal cancer according to Dukes’ stage, acetylator status, and evidence of TP53 and K-ras mutations3-150
| Period from diagnosis (y) | |||||||
|---|---|---|---|---|---|---|---|
| 0 | 1 | 2 | 3 | 4 | 5 | p Value3-151 | |
| All cases (n=100) | 100 | 87 (3) | 75 (5) | 69 (5) | 65 (6) | 65 (6) | – |
| By stage | |||||||
| A-B (n=53) | 100 | 100 | 96 (3) | 89 (6) | 89 (6) | 89 (6) | <0.001 |
| C-D (n=47) | 100 | 71 (7) | 52 (8) | 47 (8) | 39 (10) | 39 (10) | |
| Acetylator status | |||||||
| Slow (n=65) | 100 | 89 (4) | 79 (5) | 70 (7) | 70 (7) | 70 (7) | 0.261 |
| Fast (n=35) | 100 | 83 (6) | 68 (9) | 68 (9) | 59 (11) | 59 (11) | |
| K-rasmutation | |||||||
| No (n=65) | 100 | 89 (4) | 78 (6) | 70 (7) | 70 (7) | 70 (7) | 0.148 |
| Yes (n=35) | 100 | 82 (7) | 70 (8) | 66 (8) | 57 (11) | 57 (11) | |
| TP53mutation | |||||||
| No (n=45) | 100 | 91 (4) | 88 (5) | 82 (7) | 82 (7) | 82 (7) | 0.003 |
| Yes (n=55) | 100 | 83 (5) | 65 (7) | 58 (8) | 50 (10) | 50 (10) | |
| TP53 positive cases only | |||||||
| K-rasmutation | |||||||
| No (n=38) | 100 | 87 (6) | 70 (8) | 64 (10) | 64 (10) | 64 (10) | 0.046 |
| Yes (n=17) | 100 | 76 (10) | 53 (12) | 46 (12) | 23 (17) | 23 (17) | |