Table 1

Effect of folate deficiency on weight, haemoglobin concentration, and serum, liver, and colon folate concentrations

Study 1Study 2AStudy 2B
ControlDeficientControlDeficientControlDeficient
Weight1-151 261.8  (35.7)262.0  (15.6)344.1  (27.2)291.3  (6.8)** 543.6  (24.4)571.3  (31.6)
Haemoglobin (g/dl)13.0 (0.4)11.9 (0.9)14.3 (0.7)10.6 (1.9)** 14.9 (2.1)14.8 (1.7)
Serum folate (ng/ml)106.4 (18.7)3.3 (1.7)** 73.0 (20.3)10.9 (14.2)** 51.8 (19.0)23.9 (19.5)**
Liver folate (μg/g)1-152 7.6 (1.5)1.2 (0.3)** 8.8 (2.0)0.4 (0.1)** 5.5 (4.4)1.8 (1.0)1-150
Colon folate (ng/g)1-152 666.1 (92.0)139.8 (55.8)** 702.4 (178.3)13.4 (5.8)** 656.3 (83.1)464.3 (87.6)1-150
  • Results are expressed as mean (SEM).

  • Study 1, excision repair study in severely folate deficient rats; study 2A, mismatch repair study in severely folate deficient rats; study 2B, mismatch repair study in DMH treated folate deficient rats.

  • 1-150 p < 0.05; **p < 0.01 control v deficient.

  • 1-151 Weight measured at time of death.

  • 1-152 Concentration expressed per g tissue wet weight.