Effect of folate deficiency on weight, haemoglobin concentration, and serum, liver, and colon folate concentrations
| Study 1 | Study 2A | Study 2B | ||||||
|---|---|---|---|---|---|---|---|---|
| Control | Deficient | Control | Deficient | Control | Deficient | |||
| Weight1-151 | 261.8 (35.7) | 262.0 (15.6) | 344.1 (27.2) | 291.3 (6.8)** | 543.6 (24.4) | 571.3 (31.6) | ||
| Haemoglobin (g/dl) | 13.0 (0.4) | 11.9 (0.9) | 14.3 (0.7) | 10.6 (1.9)** | 14.9 (2.1) | 14.8 (1.7) | ||
| Serum folate (ng/ml) | 106.4 (18.7) | 3.3 (1.7)** | 73.0 (20.3) | 10.9 (14.2)** | 51.8 (19.0) | 23.9 (19.5)** | ||
| Liver folate (μg/g)1-152 | 7.6 (1.5) | 1.2 (0.3)** | 8.8 (2.0) | 0.4 (0.1)** | 5.5 (4.4) | 1.8 (1.0)1-150 | ||
| Colon folate (ng/g)1-152 | 666.1 (92.0) | 139.8 (55.8)** | 702.4 (178.3) | 13.4 (5.8)** | 656.3 (83.1) | 464.3 (87.6)1-150 |
Results are expressed as mean (SEM).
Study 1, excision repair study in severely folate deficient rats; study 2A, mismatch repair study in severely folate deficient rats; study 2B, mismatch repair study in DMH treated folate deficient rats.
↵1-150 p < 0.05; **p < 0.01 control v deficient.
↵1-151 Weight measured at time of death.
↵1-152 Concentration expressed per g tissue wet weight.