Table 2

Symptoms at diagnosis in patients with selective IgA deficiency (SIgAD) and in those with normal serum IgA (controls)

SIgAD Control
Classic forms n=31 (%)n=1306 (%)
Chronic diarrhoea29 (93.5)1176 (90)
Weight loss29 (93.5)1176 (90)
Abdominal distension27 (87)1136 (87)
Vomit26 (83.9)1069 (81.8)
Atypical forms n=16 (%)n=636 (%)
Short stature3-150 6 (37.8)201 (31.6)
Iron deficiency anaemia4 (25)213 (33.4)
Increased transferases1 (6.3)18 (2.8)
Recurrent abdominal pains with constipation1 (6.3)30 (4.7)
Dermatitis herpetiformis1 (6.3)31 (4.8)
Recurrent aphthous stomatitis3 (18.7)56 (8.8)
Epilepsy and cerebellar calcification1 (6.3)11 (1.7)
Miscellaneous66 (10.4)
Silent forms (serological screening in risk groups) n=7 (%) n=102 (%)
IDDM1 (14.2)34 (33.3)
Other autoimmune diseases6 (5.9)
First degree relatives3 (42.6)30 (29.4)
School screening1 (14.2)14 (13.7)
SIgAD2 (28.4)
Down’s syndrome11 (10.8)
Turner’s syndrome2 (2)
Neurological diseases5 (4.9)
  • 3-150 < to the third percentile for age.

  • IDDM, insulin dependent diabetes mellitus.