Associated diseases in patients with selective IgA deficiency (SIgAD) and in those with normal serum IgA (controls)
| SIgAD (n = 54) (%) | Control (n = 2044) (%) | |
| Recurrent infections | 16 (29.6) | 59 (2.9) |
| Respiratory tract | 14 | 43 |
| Urinary tract | 2 | 3 |
| Gastrointestinal tract | – | 13 |
| Allergic diseases | 7 (13) | 95 (4.6) |
| Asthma | 2 | 28 |
| Atopic dermatitis | 3 | 23 |
| Gastrointestinal allergy | 2 | 6 |
| Chronic urticaria | – | 6 |
| Allergic rhinitis | – | 28 |
| Allergy to drugs | – | 4 |
| Autoimmune diseases | 3 (5.5) | 111 (5.4) |
| Insulin dependent diabetes mellitus (IDDM) | 2 | 86 |
| IDDM + autoimmune thyroiditis | – | 1 |
| Autoimmune thyroiditis + autoimmune hepatitis | – | 2 |
| Autoimmune hepatitis | – | 3 |
| Scleroderma | – | 1 |
| Thrombocytopenic purpura | – | 1 |
| Arthritis | – | 5 |
| Uveitis | 1 | – |
| Thyroiditis | – | 4 |
| Autoimmune polyendocrinopathy | – | 1 |
| Miscellaneous | – | 7 |
| Malignant diseases | – | 5 (0.2) |
| Burkitt’s lymphoma | – | 1 |
| Intestinal lymphoproliferative disease | – | 1 |
| Leukaemia | – | 1 |
| Medulloblastoma | – | 1 |
| Waldestrom blastoma | – | 1 |
| Chromosomal diseases | – | 22 (1.1) |
| Down’s syndrome | – | 16 |
| Down’s syndrome + IDDM | – | 1 |
| Down’s syndrome + autoimmune thyroiditis + autoimmune hepatitis + myelomonocytic leukaemia | – | 1 |
| Turner’s syndrome | – | 3 |
| Turner’s syndrome + IDDM | – | 1 |
| Neurological diseases | 1 (1.9) | 17 (0.8) |
| Epilepsy and cerebellar calcification | 1 | 11 |
| Epilepsy | – | 3 |
| Psycomotor encephalopathy | – | 3 |
| Other associations | 6 (11.1) | 205 (10) |
| Dermatitis herpetiformis | 1 | 31 |
| Increase of transaminases | 1 | 101 |
| Dental enamel hypoplasia | 1 | 10 |
| Psoriasis | – | 3 |
| Infertility | – | 4 |
| Aphthous stomatitis | 3 | 56 |
Recurrent infections: SIgAD v control p < 0.00001; allergic diseases: SIgAD v control p < 0.02.