Liver function tests after injection of d-galactosamine or saline (control)
| 24 h | 36 h | 42 h | 48 h | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| d-galactosamine | Control | d-galactosamine | Control | d-galactosamine | Control | d-galactosamine | Control | ||||
| Alanine aminotransferase (U/l) | |||||||||||
| 1673 (289)1-160 | 44.7 (3.8) | 5723 (655)1-160 | 48.2 (3.3) | 8779 (501)1-160 | 50.7 (2.9) | 10606 (681)1-160 | 55.5 (6) | ||||
| (1018 to 2327) | (36.1 to 53.3) | (4240 to 7206) | (40.7 to 55.8) | (7624 to 9935) | (44.1 to 57.3) | (6291 to 14920) | (49.3 to 61.7) | ||||
| Alkaline phosphatase (U/l) | |||||||||||
| 188 (23)1-160 | 98.3 (3) | 293 (27)1-160 | 97.4 (4) | 338 (35)1-160 | 95.8 (4) | 311 (46)1-160 | 95.0 (4) | ||||
| (136.5 to 239.7) | (92.2 to 104.4) | (230.9 to 354.9) | (88.7 to 106) | (257.9 to 419.2) | (86.5 to 105) | (201.7 to 420) | (84.9 to 105.4) | ||||
| Total bilirubin (μmol/l) | |||||||||||
| 12.9 (2.0)1-160 | 4.1 (0.7) | 50.3 (4.9)1-160 | 3.8 (0.7) | 63.7 (2.8)1-160 | 4.0 (0.8) | 77.83 (6.4)1-160 | 3.0 (0.7) | ||||
| (8.3 to 17.5) | (2.5 to 5.7) | (39.3 to 61.3) | (2.2 to 5.4) | (57.3 to 70.1) | (2.3 to 5.8) | (61.3 to 94.4) | (1.1 to 4.9) | ||||
| Total protein (g/l) | |||||||||||
| 47.1 (1.2)1-160 | 60.1 (1.5) | 43.1 (1.4)1-160 | 57.3 (1.4) | 42.1 (1.8)1-160 | 60.8 (1.8) | 39.4 (1.9)1-160 | 57.0 (0.8) | ||||
| (44.3 to 50) | (56.6 to 63.6) | (40.0 to 46.2) | (54.4 to 60.3) | (38.1 to 46.1) | (56.8 to 64.9) | (34.9 to 43.8) | (53.9 to 60.1) | ||||
| Albumin (g/l) | |||||||||||
| 26.1 (0.7) | 27.9 (1.0) | 24.5 (1.0)1-160 | 29.3 (1.0) | 24.6 (0.9)1-160 | 31.3 (0.9) | 22.3 (1.1)1-160 | 29.8 (1.3) | ||||
| (24.5 to 27.7) | (25.6 to 30.1) | (22.3 to 26.7) | (26.9 to 31.5) | (22.7 to 26.5) | (29.2 to 33.4) | (19.7 to 24.8) | (26.6 to 32.9) | ||||
| Globulin (g/l) | |||||||||||
| 21 (0.9)1-160 | 27.9 (0.7) | 18.6 (0.7)1-160 | 32.8 (1.5) | 17.5 (1.0)1-160 | 31.5 (0.8) | 17.1 (0.9)1-160 | 29.9 (1.2) | ||||
| (18.9 to 23.1) | (26.2 to 29.6) | (16.9 to 20.2) | (29.6 to 36.04) | (15.3 to 19.7) | (29.6 to 33.4) | (15 to 19.2) | (27.0 to 32.8) | ||||
| Aminopyrine breath test constant (1×10−2/min) | |||||||||||
| 7 (0.2)1-160 | 12.0 (0.4) | 5.2 (0.3)1-160 | 12.1 (0.4) | 4.4 (0.2)1-160 | 12.1 (0.2) | 4.1 (0.5)1-160 | 11.9 (0.4) | ||||
| (6.5 to 7.5) | (11.1 to 13.0) | (4.6 to 5.8) | (11.2 to 13.0) | (4.0 to 4.9) | (11.0 to 13.2) | (2.9 to 5.3) | (11.0 to 12.9) | ||||
Results are expressed as mean (SEM) (95% confidence interval).
↵1-160 p<0.01.