Table 4

Linkage disequilibrium between HFE and HLA class I and II alleles

Haplotype Haplotype count Haplotype frequency χ2 χ2p Δs r
282Y–A*03330.0515.86<0.00010.410.22
282Y–B*07260.040.91NS0.260.05
282Y–C*0702270.041.39NS0.270.06
282Y–DRB1*15330.055.690.0090.390.13
282Y–DQB1*0602320.056.40.0060.380.14
63D–A*29130.026.380.0060.110.14
  • Haplotype counts were obtained by counting the number of controls positive for both alleles on a haplotype. Haplotype frequencies were calculated by dividing the number of counted haplotypes by the total number of chromosomes studied (660). Haplotypes are listed as combinations of 282Y or 63D with class I or II alleles for convenience; however, data are identical for haplotypes listed as 63–282–class I/II combinations. This is because 282Y is only found with 63H and 63D with 282C—for example, the 282Y–A*03 date are identical to 63H–282Y–A*03 data. 63H and 282C are not in linkage disequilibrium with class I or II alleles because of the high frequencies of these alleles.

  • Δs, Δ standardised; r, correlation coefficient (for deviation, see text).