Release of TNF and inhibitors in the tissue culture study
| Measured cytokine | Normal controls (n=14) | Inflammatory controls (n=8) | Involved mucosa | Non-involved mucosa | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| CD (n=35) | UC (n=35) | CD (n=30) | UC (n=22) | ||||||||
| TNF-α | 5.6 (4.6–8.4) | 16.9 (9.0–30.8) | 49.2 (25–100)5-150 † | 42.5 (24.0–79.2)5-150 † | 18.7 (9.4–25.8)5-150 | 3.8 (2.1–13.0) | |||||
| TNF-β | 1.4 (1.06–1.8) | 1.94 (1.4–2.38) | 2.78 (1.65–3.78)5-150 | 1.5 (1.06–1.64) | 1.5 (1.4–2.9) | 1.5 (1.3–2.3) | |||||
| sTNF-R1 | 100 (62–130) | 124 (112–138) | 118 (72–191) | 71 (53–101) | 140 (85–148) | 148 (132–178) | |||||
| sTNF-R2 | 58 (32–72) | 88 (82–95) | 208 (158–335)5-150 | 205 (120–272)5-150 | 58 (55–120) | 53 (35–92) | |||||
Cytokine levels and soluble receptors levels are given as pg/mg tissue wet weight, and all data are presented as median (interquartile range).
↵5-150 p<0.01 v normal controls; †p<0.01v inflammatory controls.
UC, ulcerative colitis; CD, Crohn’s disease.