Table 1

Risks of colorectal cancer in relation to aspirin or NSAID use

Odds ratio 95% CI Dose/duration
Aspirin
Peleg and coworkers4 0.080.01–0.59>624 days any dose
0.520.30–0.91<208 days any dose
Rosenberg and coworkers5 0.50.4–0.81 year or more any dose
0.50.2–0.9<1 year any dose
Kune and coworkers6 0.530.40–0.71Any dose or duration
Giovannucci and coworkers7 0.090.02–0.43Over 5 years1-150
0.230.09–0.54Over 3 years1-151
0.520.32–0.84In 1 year1-152
Logan and coworkers8 (adenomas)0.720.4–1.3Any use
Non-aspirin NSAID
Peleg and coworkers4 0.340.15–0.77>350 days
0.770.48–1.23<350 days
Kune and coworkers6 0.770.60–1.01Any use
Aspirin or non-aspirin NSAID
Logan and coworkers8(adenomas)0.720.3–1.6Prescribed use

  • ↵1-150 Affirmative responses to questionnaires two years apart on three occasions.

  • ↵1-151 Affirmative responses to questionnaires two years apart on two occasions.

  • ↵1-152 Affirmative responses to a single questionnaire.

  • CI, confidence interval.