Table 1

Characteristics of contraction induced by platelet activating factor (PAF) and prostaglandin E2(PGE2) after intestinal inflammation provoked by trinitrobenzenesulphonic acid

PAFPGE2
Day of inflammationMaximal contractionCmax (nM)EC50 (pM)Maximal contractionCmax (nM)EC50 (pM)
114.9 (0.4)1020 (3)12.6 (2.2)106 (0.4)
214.4 (0.8)104 (0.5)14.1 (2.3)100* 50 (5)
316.0 (0.6)1060 (4)13.3 (5.9)1000** 900 (40)
414.3 (1.9)100* 400 (20)13.4 (1.3)100* 200 (60)
513.1 (1.1)1000** 600 (60)12.8 (2.8)100* 50 (3)
615.5 (2.7)1000** 950 (70)15.8 (2.7)100* 200 (50)
1014.4 (0.9)108 (0.3)14.6 (0.1)1020 (6)
1515.8 (2.1)1040 (6)15.7 (1.8)1010 (3)
  • Where applicable, values are mean (SEM) (n=5).

  • Cmax, concentration of agonist inducing a maximal effect; EC50, concentration of agonist inducing 50% of the maximal effect.

  • Values significantly different from those obtained in cells from control animals: *p<0.05, **p<0.01.