Table 1

Compositions of the three test solutions used for the intestinal permeability studies

Hypo-osmolar (12 mmol/l) Iso-osmolar (244 mmol/l) Hyperosmolar (1500 mmol/l)
3-0-methyl-d-glucose0.2 g0.2 g
d-xylose0.5 g0.5 g
l-rhamnose1.0 g1.0 g1.0 g
Lactulose5.0 g5.0 g
51Cr-EDTA50–100 μCi
Glycerol9.2 ml
  • Inclusion of 3-0-methyl-d-glucose allows assessment of active carrier mediated transport and d-xylose passive carrier mediated transport.

  • l-rhamnose assesses “small pore” predominantly non-mediated transcellular transport and lactulose and51Cr-EDTA assess non-mediated “large pore” paracellular transport.33 The differential urinary excretion of51Cr-EDTA/l-rhamnose or lactulose/l-rhamnose provides a specific index of intestinal permeability.