Table 2

Intestinal absorptive capacity and intestinal permeability assessed at three different test dose osmolarities

ControlIndomethacinPiroxicamNaproxenIbuprofenFlurbiprofenSulindac
Iso-osmolar test
3-0-methyl-d-glucose43.6 (6.8)%28.9 (8.5)%3-150 31.0 (9.9)%3-150 24.6 (7.7)%3-150 24.7 (10.6)%3-150 29.2 (11.5)%24.8 (9.4)%3-150
d-xylose29.5 (3.2)%18.4 (4.0)%3-160 20.9 (7.9)%3-150 16.7 (5.7)%3-160 20.2 (13.9)%3-150 22.2 (4.4)%3-150 18.3 (7.7)%3-150
l-rhamnose10.5 (1.9)%7.7 (2.6)%3-150 8.4 (3.7)%3-150 5.7 (2.1)%3-160 6.5 (4.3)%3-150 7.2 (3.1)%6.9 (2.8)%
Lactulose0.267 (0.110)%0.356 (0.185)%0.416 (0.338)0.212 (0.085)%0.280 (0.1400.401 (0.219)%0.338 (0.231)%
Lactulose:l-rhamnose0.029 (0.010)0.056 (0.041)3-150 0.057 (0.045)3-150 0.057 (0.062)3-150 0.054 (0.029)3-150 0.060 (0.044)3-150 0.056 (0.064)3-150
Hyperosmolar test
3-0-methyl-d-glucose43.7 (4.7)%29.0 (11.3)%3-150 26.8 (11.3)%3-150 29.3 (10.8)%27.5 (9.7)%3-150 28.3 (13.2)%3-150 30.1 (5.2)%3-150
d-xylose30.2 (4.8)%17.8 (6.7)%3-160 15.1 (6.1)%3-160 17.6 (5.3)%3-160 17.1 (7.07)%3-150 25.7 (8.8)%19.9 (8.5)%3-150
l-rhamnose11.1 (2.1)%6.7 (2.3)%3-150 6.3 (2.9)%3-150 6.7 (1.7)%3-150 7.8 (3.9)%3-150 5.8 (3.2)%3-150 6.2 (5.1)%3-150
Lactulose0.361 (0.100)%0.775 (0.451)%3-150 0.588 (0.265)%0.702 (0.434)%3-150 0.844 (0.715)%3-150 0.775 (0.331)%0.619 (0.444)%
Lactulose:l-rhamnose0.034 (0.011)0.127 (0.099)3-160 0.091 (0.048)3-160 0.106 (0.060)3-160 0.107 (0.074)3-160 0.112 (0.065)3-160 0.097 (0.081)3-160
Hypo-osmolar test
l-rhamnose12.3 (2.4)%10.8 (2.8)%9.20 (3.73)%10.2 (5.2)%10.1 (5.0)%12.1 (4.8)%11.6 (3.6)%
51Cr-EDTA0.61 (0.26)%1.33 (0.71)%3-150 1.13 (0.52)%3-150 1.16 (0.79)%3-150 0.72 (0.37)%1.29 (0.63)%3-150 1.15 (0.89)%3-150
51Cr-EDTA:l-rhamnose0.05 (0.02)3-160 0.13 (0.06)3-160 0.10 (0.05)3-160 0.12 (0.06)3-160 0.12 (0.08)3-160 0.14 (0.09)3-160 0.11 (0.05)3-160

  • Values represent mean (SD) five hour urinary excretion (% dose) or differential excretion of the test probes.

  • ↵3-150 Differs significantly (ANOVA) from control, p<0.05.

  • ↵3-160 Differs significantly (ANOVA) from control, p<0.01.