Influence of nitric oxide on vital signs, pancreatic secretion and pancreatic histology in patients with pancreatitis
| Control | Caerulein | +L-arginine | +SNP | +l-NAME | |
| MAP | |||||
| 0 hours | 124 (2) | 128 (3) | 121 (2) | 126 (2) | 124 (2) |
| 6 hours | 125 (2) | 127 (2) | 114 (2)† | 117 (1)† | 138 (2)† |
| HR | |||||
| 0 hours | 329 (8) | 328 (7) | 338 (6) | 332 (6) | 330 (7) |
| 6 hours | 329 (6) | 339 (7) | 326 (7) | 337 (6) | 340 (6)‡ |
| Amylase (U/l) | 11 (4) | 381 (35)1-150 | 122 (31)† | 161 (34)† | 297 (44) |
| TAP (serum, nmol/l) | 1.43 (0.44) | 4.19 (1.04)1-150 | 1.43 (0.38)† | 2.72 (1.32)† | 14.12 (4.81) |
| TAP (tissue, nmol/g) | 92 (11) | 223 (27)1-150 | 135 (22)‡ | 153 (31)‡ | 398 (56)‡ |
| Oedema | 3.13 (0.1) | 12.15 ±0.73)1-150 | 5.47 (0.56)† | 6.04 (0.39)† | 8.76 (0.32)† |
| Inflammation | 0.00 (0.00) | 0.85 (0.07)1-150 | 0.035 (0.89)† | 0.55 (0.06)† | 1.03 (0.03)‡ |
| Necrosis | 0.05 (0.03) | 0.63 (0.06)1-150 | 0.035 (0.09)‡ | 0.58 (0.05) | 0.56 (0.04) |
↵1-150 p<0.005 compared with control; †p<0.005 compared with caerulein; ‡p<0.05 compared with caerulein.