Course of inflammatory bowel disease (IBD) after orthotopic liver transplantation (OLT) compared with the IBD course before OLT in published studies
| IBD course after OLT | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Reference | Maintenance immunosuppression | Follow up after OLT (months) | Pre-OLT IBD activity | No of patients | Sex (M/F) | Age (years) | Same (n (%)) | Better (n (%)) | Worse (n (%)) |
| Gavaler et al 12 | Cyclosporin+prednisolone | NA | Total | 23 | 15/8 | NA | 9 (39) | 14 (61) | 0 |
| 110 | Quiescent | 6 | 4/2 | 35 | 6 (100) | 0 | 0 | ||
| 83 | Active | 17 | 11/6 | 40 | 3 (18) | 14 (82) | 0 | ||
| Shaked et al 13 | Cyclosporin or | 30 | Total | 24 | NA | NA | 12 (50) | 4 (17) | 8 (33) |
| tacrolimus+azathioprine+ | NA | Quiescent | 13 | NA | NA | 9 (69) | 0 | 4 (31) | |
| prednisolone | NA | Active | 11 | NA | NA | 3 (28) | 4 (36) | 4 (36) | |
| Stephenset al 15 | Cyclosporin or tacrolimus+prednisolone+ azathioprine5-150 | NA | Total | 27 | NA | NA | 4 (15) | 18 (67) | 5 (18) |
| Befeleret al 26 | Cyclosporin or | 37 | Total | 23 | NA | NA | 12 (52) | 11 (48) | 0 |
| tacrolimus+azathioprine+ | NA | Quiescent | 6 | NA | NA | 6 (100) | 0 | 0 | |
| prednisolone | NA | Active | 17 | NA | NA | 6 (35) | 11 (65) | 0 | |
| This study | Cyclosporin or | 39 | Total | 16 | 11/5 | 36 | 8 (50) | 0 | 8 (50) |
| tacrolimus±azathioprine | 36 | Quiescent | 12 | 8/4 | 35 | 8 (67) | 0 | 4 (33) | |
| 48 | Active | 4 | 3/1 | 39 | 0 | 0 | 4 (100) | ||
↵5-150 Azathioprine or cyclophosphamide.