Table 2

Clinical details in familial and sporadic Crohn’s disease

Familial Crohn’s disease (n=152) Sporadic Crohn’s disease (n=1164) p Value
Male/female63/89458/706NS
Age at diagnosis (years)3-150 26.8  (12.1)28.9  (12.9)0.06
Delay between onset of symptoms and diagnosis (months)3-150 19.1 (37.5)15.8 (32.8) NS
Mean duration of illness (months)3-150 125 (112) 92 (88)0.0005
Ethnicity
 Non-Jewish whites88 (58%)927 (80%)<10-6
 Jews43 (28%)126 (11%)<10-6
 Arabs19 (12%)83 (7%)0.02
 Asians02 (0.2%)NS
 Blacks2 (1%)26 (2%)NS
Smoking status
 Smokers85 (56%)626 (54%)NS
 Non-smokers57 (37%)420 (36%)NS
 Unknown10 (7%)118 (10%)NS
Initial site of disease
 Colon only 43 (28%)381 (33%)NS
 Small bowel only 42 (28%)372 (32%)NS
 Small bowel and colon65 (43%)399 (34%)0.04
 Other2 (1%)12 (1%)NS
Anoperineal disease at onset25 (16%)252 (22%)NS
Extra-intestinal manifestations 57 (38%)422 (36%)NS
  • 3-150 Mean (SD).