Table 3

Lactulose:mannitol (L/M) ratio in five hour urinary excretion at baseline and after ingestion of acetylsalicylic acid (ASA)

Patients (n=39)Relatives (n=34)Spouses (n=22)Controls (n=29)Solely relatives (n=11)Spouses at diagnosis (n=9)
L/M at baseline1 0.016 (0.012–0.024)5-150 0.011 (0.009–0.017)0.014 (0.011–0.019)5-150 0.011 (0.009–0.014)0.011 (0.009–0.013)0.015 (0.011–0.020)
Proportion with raised L/M at baseline 2 14/39 (36%)5-150 6/34 (18%)5/22 (23%)1/29 (3%)1/11 (9%)3/9 (33%)5-150
L/M after ASA3 0.025 (0.021–0.035)5-150 0.028 (0.018–0.038)5-150 0.020 (0.016–0.026)0.017 (0.015–0.021)0.028 (0.016–0.029)0.019 (0.018–0.025)
Proportion with abnormal L/M increase by ASA4 11/34 (32%)5-150 13/32 (41%)5-150 3/21 (14%)1/29 (3%)3/11 (27%)5-150 0/9 (0%)
  • Data are presented as median (interquartile range).

  • 1Kruskal-Wallis: H = 14.3; degrees of freedom (DF) = 3; p = 0.003.

  • 2 χ2 = 10.9; DF = 3; p = 0.012.

  • 3Increased L/M ratio in all groups, p<0.005 (paired sign test). Kruskal-Wallis: H = 13.5; DF = 3; p = 0.004.

  • 4 χ2 = 14.6; DF = 3; p = 0.002.

  • 5-150 p<0.05 compared with controls (Mann-Whitney or Fisher’s exact test).