Lactulose:mannitol (L/M) ratio in five hour urinary excretion at baseline and after ingestion of acetylsalicylic acid (ASA)
| Patients (n=39) | Relatives (n=34) | Spouses (n=22) | Controls (n=29) | Solely relatives (n=11) | Spouses at diagnosis (n=9) | |
| L/M at baseline1 | 0.016 (0.012–0.024)5-150 | 0.011 (0.009–0.017) | 0.014 (0.011–0.019)5-150 | 0.011 (0.009–0.014) | 0.011 (0.009–0.013) | 0.015 (0.011–0.020) |
| Proportion with raised L/M at baseline 2 | 14/39 (36%)5-150 | 6/34 (18%) | 5/22 (23%) | 1/29 (3%) | 1/11 (9%) | 3/9 (33%)5-150 |
| L/M after ASA3 | 0.025 (0.021–0.035)5-150 | 0.028 (0.018–0.038)5-150 | 0.020 (0.016–0.026) | 0.017 (0.015–0.021) | 0.028 (0.016–0.029) | 0.019 (0.018–0.025) |
| Proportion with abnormal L/M increase by ASA4 | 11/34 (32%)5-150 | 13/32 (41%)5-150 | 3/21 (14%) | 1/29 (3%) | 3/11 (27%)5-150 | 0/9 (0%) |
Data are presented as median (interquartile range).
1Kruskal-Wallis: H = 14.3; degrees of freedom (DF) = 3; p = 0.003.
2 χ2 = 10.9; DF = 3; p = 0.012.
3Increased L/M ratio in all groups, p<0.005 (paired sign test). Kruskal-Wallis: H = 13.5; DF = 3; p = 0.004.
4 χ2 = 14.6; DF = 3; p = 0.002.
↵5-150 p<0.05 compared with controls (Mann-Whitney or Fisher’s exact test).