Clinical and laboratory characteristics of patients with liver cirrhosis
| Variable | Controls (n=14) | Grade A cirrhosis (n=7) | p Value (A v B) | Grade B cirrhosis (n=17) | p Value (B v C) | Grade C cirrhosis (n=9) | p Value (A v C) |
| Mean (SD) age (y) | 52 (16) | 57 (11) | NS | 62 (8) | NS | 59 (17) | NS |
| No of men (%) | 6 (43) | 5 (71) | NS | 11 (65) | NS | 7 (78) | NS |
| Unstimulated TF activity (U/2 × 105 monocytes) H=19.9, p<0.0001 | 0 (<1.0–9) | 3.0 (<1.0–15) | NS | 11.0 (<1.0–32) | <0.05 | 41 (29–55) | <0.05 |
| LPS (200 pg/ml) stimulated TF activity (U/2 × 105 monocytes) H=12.5, p<0.002 | 9 (4–22) | 22 (6–45) | NS | 30 (13–50) | <0.05 | 42 (33–64) | <0.05 |
| Unstimulated TF antigen (pg/2 × 105 monocytes) H=17.0, p<0.001 | 11 (<10–15) | 17 (11–40.2) | NS | 24 (10–79) | <0.05 | 80 (54–142.6) | <0.05 |
| LPS (200 pg/ml) stimulated TF antigen (pg/2 × 105 monocytes) H=15.8, p<0.001 | 16 (10–40) | 48 (19.4–68.6) | <0.05 | 62 (23.6–98.9) | <0.05 | 81.1 (62.5–144) | <0.05 |
| F1+2 (nM) (95% CI) F=40.7, p<0.0001 | 0.6 (0.3) (0.4–0.8) | 0.9 (0.3) (0.7–1.2) | <0.05 | 1.5 (0.6) (1.2–1.8) | <0.05 | 3.4 (0.7) (2.8–3.9) | <0.05 |
| Endotoxaemia (pg/ml) H=22.6, p<0.0001 | 4.1 (0–9.6) | 13.4 (4.4–17.5) | <0.05 | 20.5 (10.5–36.5) | <0.05 | 72 (43–137.5) | <0.05 |
H, Kruskal-Wallis test among Child-Pugh classes; TF, tissue factor; F, analysis of variance among Child-Pugh classes; F1+2, human prothrombin fragment F1+2.