Table 3

Frequency of increased iron indexes in heterozygotes

Genotype	No of subjects	Raised transferrin saturation^5-151(>50.5%)	Raised serum ferritin concentration^5-152 (M >428, F >302 μg/l)
Compound heterozygosity	19	5 (26.3)^***	3 (15.8)^5-160
C282Y heterozygous	121	11 (9.1)^5-160	11 (9.1)^***
H63D heterozygous	240	24 (10.0)^***	10 (4.2)
Normal (noHFE mutation)	655	21 (3.2)	16 (2.4)

Results are expressed as number (%).
↵5-151 Mean transferrin saturation of the normal (no HFE gene mutation) genotype group plus two standard deviations.
↵5-152 97.5th percentile for serum ferritin concentration for male and female subjects without an HFE gene mutation.
↵5-160 p<0.01, ^***p<0.001.