Effect of non-specific NOS inhibitors, L-NAME and L-NMA and the nNOS inhibitor, 7-nitroindazole on cholera toxin (CT) induced net small intestinal chloride and sodium movement
| Number | Net Cl−flux (μmol/min/g) | Net Na+ flux (μmol/min/g) | |
| CT | 16 | −12.3 (−15.3 to −11.3) | −16.9 (−18.0 to −15.2) |
| + l-NAME 20 mg/kg | 8 | −10.03-150 (−10.7 to −7.2) | −12.73-150 (−15.0 to −10.9) |
| + l-NAME 40 mg/kg | 9 | −3.5† (−5.3 to −2.5) | −6.4† (−8.2 to −5.0) |
| + l-NAME 60 mg/kg | 6 | −5.9† (−7.9 to −4.8) | −6.9† (−8.6 to −4.7) |
| + l-NMA 50 mg/kg | 6 | −4.7† (−6.3 to −1.7) | −3.9† (−4.4 to −0.4) |
| + 7-nitroindazole 50 mg/kg | 11 | −10.8 (−11.9 to −8.8) | −13.4 (−17.2 to −12.8) |
| + 7-nitroindazole 100 mg/kg | 6 | −10.5 (−12.6 to −8.4) | −15.2 (−16.3 to −14.1) |
| + peanut oil 10 mg/kg | 6 | −11.0 (−11.5 to −9.7) | −16.5 (−17.2 to −15.1) |
Data are expressed as median and interquartile ranges.
↵3-150 p<0.002 versus cholera toxin; †p<0.0001 versus cholera toxin.