Baseline estimates used in the decision model
| Variable | Interpretation | Baseline value | References |
|---|---|---|---|
| pSens | Sensitivity of genetic strategy for APC mutation in proband | 0.74 | 18,23 |
| p15 | Proportion of relatives between ages 10 and 20 years | 0.60 | 1-151 |
| p25 | Proportion of relatives between ages 20 and 30 years | 0.20 | 1-151 |
| p35 | Proportion of relatives between ages 30 and 40 years | 0.20 | 1-151 |
| pCarry | Risk of carrying APC mutation | 0.50 | 1, 2 |
| pExp | Degree of expression ofAPC mutation | 0.90 | 23 |
| p20 | Detection of FAP polyps between ages 15 and 25 years | 0.90 | 1-151 |
| p30 | Detection of FAP polyps between ages 25 and 35 years | 0.99 | 1-151 |
| p40 | Detection of FAP polyps between ages 35 and 50 years | 1.00 | 1-151 |
↵1-151 Authors’ estimates.