K-ras point mutations in codons 12 and 13 in colorectal adenomas
| Codon 12 (amino acid) | Codon 13 (amino acid) | Type of mutation4-150 | Percentage of adenomas (number) |
|---|---|---|---|
| Wild type GGT (Gly) | Wild type GGC (Gly) | — | 65 (131) |
| Single mutation | |||
| GAT (Asp) | Wild type | S @ 12b | 11 (23) |
| GTT (Val) | Wild type | V @ 12b | 9 (18) |
| GCT (Ala) | Wild type | V @ 12b | 1 (2) |
| TGT (Cys) | Wild type | V @ 12a | 4 (9) |
| Wild type | GAC (Asp) | S @ 13b | 1 (2) |
| Wild type | GTC (Val) | V @ 13b | 0.5 (1) |
| Double mutations | |||
| GAT (Asp), GTT (Val) | Wild type | S @ 12b, V @ 12b | 2 (5) |
| TGT (Cys), GAT (Asp) | Wild type | V @ 12a, S @ 12b | 2 (4) |
| TGT (Cys), GTT (Val) | Wild type | V @ 12a, V @ 12b | 1 (2) |
| TGT (Cys), GCT (Ala) | Wild type | V @ 12a, V @ 12b | 0.5 (1) |
| GCT (Ala), GAT (Asp) | Wild type | V @ 12b, S @ 12b | 1 (2) |
| GCT (Ala), GTT (Val) | Wild type | V @ 12b, V @ 12b | 0.5 (1) |
↵4-150 Transition denoted by S, transversion by V, followed by codon (12 or 13) and nucleotide 1 (a) or 2 (b).