Tumour spectrum of the affected relatives in the 22 families with identified germline mutations (the index patients are not included)
| Germline mutation | |||||
|---|---|---|---|---|---|
| hMSH2 (n=7) | hMLH1 (n=15) | ||||
| Male | Female | Male | Female | ||
| Total number of relatives affected by a malignancy2-150 | 18 | 17 | 32 | 29 | |
| Colorectal | 13 (72%) | 9 (53%) | 28 (85%) | 19 (59%) | |
| Stomach | 2 | 1 | 1 | 1 | |
| Pancreas | 1 | 2 | |||
| Duodenum | 1 | 1 | |||
| Endometrium | 7 (41%) | 2 (6%) | |||
| Breast | 4 | ||||
| Urothelium | 2 | 1 | 1 | 1 | |
| Others | 3 | 5 | |||
↵2-150 Some patients had multiple malignant tumours.