Summary characteristics of patients with severe alcoholic hepatitis (AH), mild to moderate AH, and quiescent cirrhosis, as defined histologically
| Severe AH (n=24) | Mild/moderate AH (n=15) | Cirrhosis (n=12) | |
|---|---|---|---|
| AST (U/l) | |||
| Median | 64 | 50 | 36 |
| Range | 21–405 | 20–113 | 13–61 |
| Bilirubin (μmol/l) | |||
| Median | 232 | 100 | 54 |
| Range | 45–1050 | 14–313 | 11–550 |
| PT (s) | |||
| Median | 23 | 21 | 19 |
| Range | 17–43 | 14–39 | 15–30 |
| Discriminant function1-150 1-151 | |||
| Median | 65.2 | 40.5 | 28.4 |
| Range | 29.6–151 | 5.6–138 | 9.8–111 |
| PSE | 13 | 4 | 2 |
| Transplanted1-152 | 2 | 3 | 3 |
| Deaths1-152 | 10 | 4 | 2 |
↵1-150 After Maddrey,15 where discriminant function = [(prolongation in PT × 4.6) + (serum bilirubin/17)]. A discriminant function of >32 is indicative of a risk of mortality of at least 50%.
↵1-151 Severe AH versus mild or moderate AH, p<0.05; severe AH versus quiescent cirrhosis, p<0.05; mild to moderate AH versus quiescent cirrhosis, p<0.05 (Mann-Whitney U test).
↵1-152 Occurring within three months after serum sampling. All deaths were directly related to liver disease.
AST, aspartate aminotransferase; PT, prothrombin time; PSE, portosystemic encephalopathy (defined where clinically obvious).