Table 1

Summary characteristics of patients with severe alcoholic hepatitis (AH), mild to moderate AH, and quiescent cirrhosis, as defined histologically

Severe AH (n=24)Mild/moderate AH (n=15)Cirrhosis
AST (U/l)
Bilirubin (μmol/l)
PT (s)
Discriminant function1-150 1-151
 Range29.6–1515.6–138 9.8–111
Transplanted1-152 233
Deaths1-152 1042
  • 1-150 After Maddrey,15 where discriminant function = [(prolongation in PT × 4.6) + (serum bilirubin/17)]. A discriminant function of >32 is indicative of a risk of mortality of at least 50%.

  • 1-151 Severe AH versus mild or moderate AH, p<0.05; severe AH versus quiescent cirrhosis, p<0.05; mild to moderate AH versus quiescent cirrhosis, p<0.05 (Mann-Whitney U test).

  • 1-152 Occurring within three months after serum sampling. All deaths were directly related to liver disease.

  • AST, aspartate aminotransferase; PT, prothrombin time; PSE, portosystemic encephalopathy (defined where clinically obvious).