Table 2

Haemodynamics before and within nine hours of insertion of a transjugular intrahepatic portosystemic stent shunt (TIPS) in patients with portal hypertension

Variables measuredNormal rangeBefore TIPS5 min after TIPS90 min n=93h n=96h n=99h n=9
n=17n=9n=17n=9
HR (beats/min)70 (8)74.2 (17.8)78.3 (21.1)83.7 (13.6)** 87.1 (19.8)* 81.8 (22.6)81.6 (12.4)85.7 (13.5)86.3 (15.1)
BP, syst (mm Hg)131 (13)114 (21.4)119 (22.3)131 (20.6)* 126 (26.1)114 (19.3)115 (15.4)116 (17.9)114 (19.6)
BP, diast (mm Hg)82 (7)71.7 (10.6)74.4 (10.4)73.9 (7.2)74.4 (7.7)69.4 (11.8)68.3 (13.2)67.2 (14.1)65.6 (17.2)
PPA, syst (mm Hg)21.5 (3.9)19.1 ( 6.5)20.9 (6.9)34.5 (8.7)** 34.0 (10.3)** 26.1 (7.1)** 26.2 (6.2)** 26.2 (5.9)* 25.9 (5.6)*
PPA, diast (mm Hg)8.8 (1.8)8.9 (4.0)10.0 (5.1)18.5 (5.6)** 18.4 (6.9)** 13.6 (3.8)* 13.9 (2.9)* 14.4 (3.0)* 14 (4.2)*
PPA (mm Hg)14.4 (2.7)13.8 (5.3)15.1 (6.3)26.5 (7.2)** 25.8 (8.7)** 19.4 (5.0)* 19.0 (5.0)* 19.3 (4.5)* 19.2 (4.9)*
PPC (mm Hg)8.3 (2.9)9.4 (3.8)9.7 (4.8)19.8 (5.6)** 18.7 (6.9)** 13.6 (3.2)* 12.6 (2.5)* 12.7 (2.9)* 12.2 (2.9)
PRA (mm Hg)4.2 (1.3)5.8 (2.7)6.3 (3.0)11.6 (3.6)** 12.2 (4.3)** 8.9 (3.7)* 8.4 (3.1)* 9.2 (3.5)* 8.7 (2.9)*
CO (l/min)6.3 (2.4)8.1 (1.6)8.5 (1.7)11.9 (2.4)** 12.4 (2.1)** 9.6 (1.8)* 10.0 (1.7)* 10.2 (1.7)* 10.0 (1.7)*
SV (ml)89 (30)113 (27.2)114 (33.5)143 (31.8)** 147 (37.4)** 125 (35.8)* 127 (36.9)** 123 (30.8)* 119 (29.4)
SVR (dyn·s·cm−5)1170 (270)824 (242)820 (228)600 (265)** 538 (184)** 645 (151)** 623 (161)** 592 (129)** 601 (164)**
TPR (dyn·s·cm−5)158 (48)140 (58.5)140 (39.8)188 (69.5)* 167 (44.3)163 (37.1)153 (34.2)153 (32.4)157 (39.2)
  • Values are expressed as mean (SD). *p<0.05, **p<0.01v before TIPS.

  • HR, heart rate; BP,syst, systolic blood pressure; BP,diast, diastolic blood pressure; PPA,syst, systolic pulmonary artery pressure; PPA,diast, diastolic pulmonary artery pressure; PPA, mean pulmonary artery pressure; PPC, pulmonary capillary wedge pressure; PRA, right atrial pressure; CO, thermodilution measured cardiac output; SV, stroke volume calculated by thermodilution; SVR, systemic vascular resistance; TPR, total pulmonary resistance.