Disease (n) | p-ANCA (n) | Number of sera positive for antibodies to: | |||||
---|---|---|---|---|---|---|---|
HMG1 | HMG2 | HMG1 or 22-150 | HMG1 and 22-151 | Cathepsin G | Lactoferrin | ||
AIH (28) | Positive (25) | 22 | 232-152 | 242-153 | 21 | 23 | 5 |
Negative (3) | 1 | 1 | 1 | 1 | 2 | 0 | |
PBC (44) | Positive (16) | 12 | 12 | 13 | 11 | 15 | 1 |
Negative (28) | 14 | 16 | 18 | 12 | 23 | 4 | |
Chronic hepatitis C (27) | Positive (3) | 2 | 2 | 2 | 2 | 2 | 0 |
Negative (24) | 5 | 4 | 5 | 4 | 8 | 2 | |
Chronic hepatitis B (23) | Positive (3) | 0 | 1 | 1 | 0 | 2 | 1 |
Negative (20) | 0 | 1 | 1 | 0 | 2 | 6 |
↵2-150 Positive for antibodies to either HMG1 or HMG2.
↵2-151 Positive for antibodies to both HMG1 and HMG2.
p-ANCA, perinuclear anti-neutrophil cytoplasmic antibodies; AIH, autoimmune hepatitis; PBC, primary biliary cirrhosis.
↵2-152 p = 0.045 (Fisher’s exact test).
↵2-153 p = 0.023 (Fisher’s exact test).