Table 2

Frequencies of antibodies to HMG1, HMG2, cathepsin G, and lactoferrin

Disease (n)p-ANCA (n)Number of sera positive for antibodies to:
HMG1HMG2HMG1
or 22-150
HMG1 and 22-151Cathepsin GLactoferrin
AIH (28)Positive (25)22232-152 242-153 21235
Negative (3)111120
PBC (44)Positive (16)12121311151
Negative (28)14161812234
Chronic hepatitis C (27)Positive (3)222220
Negative (24)545482
Chronic hepatitis B (23)Positive (3)011021
Negative (20)011026
  • 2-150 Positive for antibodies to either HMG1 or HMG2.

  • 2-151 Positive for antibodies to both HMG1 and HMG2.

  • p-ANCA, perinuclear anti-neutrophil cytoplasmic antibodies; AIH, autoimmune hepatitis; PBC, primary biliary cirrhosis.

  • 2-152 p = 0.045 (Fisher’s exact test).

  • 2-153 p = 0.023 (Fisher’s exact test).