Univariate analysis of alterations in alanine aminotransferase (ALT) and γ-glutamyltranspeptidase (GGT), and the presence of chronic liver disease (CLD) and cirrhosis for non-organ-specific autoantibody (NOSA) reactivity in the population of anti-hepatitis C virus (HCV) positive subjects (n=226) and their matched case controls (n=226). HbsAg positive subjects were excluded from the analysis. Absolute number (n), percentage of row (%) and odds ratio (OR) with 95% confidential intervals (CI) are also reported
| NOSA postitive | ANA positive | SMA positive | ||||||
|---|---|---|---|---|---|---|---|---|
| Factor | n (%) | OR (95% CI) | n (%) | OR (95% CI) | n (%) | OR (95% CI) | ||
| ALT > 40 IU/l | 1.5 (1.0 to 2.7)5-150 | 0.8 (0.3 to 1.8)5-150 | 2.5 (1.1 to 5.6)5-150 | |||||
| Present (n=98) | 20 (20) | 8 (8.2) | 11 (11.2) | |||||
| Absent (n=354) | 51 (14.4) | 36 (10.2) | 17 (4.8) | |||||
| GGT > 50 IU/l | 2.9 (1.6 to 5.0)** | 2.5 (1.2 to 4.8)** | 1.8 (0.8 to 4.2) | |||||
| Present (n=86) | 25 (29) | 15 (17) | 8 (9) | |||||
| Absent (n=366) | 46 (12.6) | 29 (8) | 20 (5.5) | |||||
| CLD | 2.0 (1.7 to 2.3)5-150 | 1.3 (0.7 to 2.6) | 1.7 (0.8 to 4.0) | |||||
| Present (n=154) | 37 (24) | 18 (11.5) | 13 (8) | |||||
| Absent (n=298) | 40 (13.4) | 28 (9.4) | 19 (6.4) | |||||
| Cirrhosis/HCC | 1.9 (0.8 to 4.6) | 1.1 (0.3 to 3.9) | 1.9 (0.5 to 6.8) | |||||
| Present (n=28) | 7 (25) | 3 (11) | 3 (11) | |||||
| Absent (n=424) | 64 (15.1) | 41 (10) | 25 (5.9) | |||||
↵5-150 p<0.05, **p<0.01.
HCC, hepatocellular carcinoma.