Table 3

Effect of cholinergic modulation on postprandial antroduodenal motility

DAS frequency (cpm)DAS amplitude (%)EGG frequency (cpm) EGG
power ratio
Antral MI Duodenal MI
Placebo3.43 (0.03)14.7 (0.9)2.93 (0.04)3.2 (0.5)5.3 (0.3)5.0 (0.16)
Atropine3.52 (0.02)* 11.0 (0.5)* 3.10 (0.01)* 5.0 (0.4)* 2.4 (0.1)** 4.4 (0.12)*
Bethanechol3.19 (0.02)* 16.8 (0.5)* 2.85 (0.02)* 9.7 (1.4)* 5.4 (0.2)5.1 (0.1)
  • Results expressed as mean (SEM). *p<0.05, **p<0.01 versus placebo using ANOVA followed by Student’s ttest (paired samples; two tailed) with Bonferroni correction factor.

  • Electrogastrography (EGG) power ratio in this table is the ratio of the power of the dominant frequency after the meal with the study drug divided by the power of the dominant frequency in the fasting period before study drug administration.

  • MI, motility index; DAS, dynamic antral scintigraphy.