Table 4

Observed and expected haplotype sharing between various affected relative pairs

RelationNumber of pairs Ni Pi 7-150 NiPi(1−Pi)Expected number NiPi Observed number Ti
Sibs520.75009.750039.0048
Avuncular7-151 90.50002.25004.506
1st cousin60.25001.12501.502
1st cousin once removed40.12500.43750.501
2nd cousin70.06250.41020.441
Great uncle10.06250.05860.060
Total7914.031346.0058
Z=3.07p=0.001
  • 7-150 Expected probability of sharing a haplotype identical by descent.

  • 7-151 Uncle/aunt—niece/nephew.