Histological and genomic parameters in 53 H pylori positive patients with chronic gastritis before and after eradication therapy
| Before therapy (n=53) | After therapy | p Value | |||||
|---|---|---|---|---|---|---|---|
| H pylori eradicated (n=45) | H pylori persisted (n=5) | ||||||
| Atrophy | 26 (49) | 16 (35) | 5 (100) | NS | |||
| Intestinal metaplasia | 185-150 (34) | 10 (22) | 4†(80) | NS | |||
| Dysplasia | 3 (6) | 0 | 3 (60) | NS | |||
| DNA aneuploidy | 11 (21) | 0 | 3 (60) | 0.01 | |||
| p53 | 8 (15) | 0 | 2 (40) | 0.05 | |||
| c-Myc | 8 (15) | 0 | 3 (60) | 0.05 | |||
Values in parentheses are percentages. p Value was calculated using the McNemar test comparing before and after therapy regardless of the outcome of treatment. The eradication treatment consisted of 15 days on omeprazole 20 mg twice a day, clarithromycin 500 mg twice a day, and tinidazole 500 mg twice a day. Three subjects dropped out during follow up.
↵5-150 16 complete and two incomplete intestinal metaplasias; †two complete plus two incomplete intestinal metaplasias.